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Clinical and Translational Oncology

, Volume 19, Issue 1, pp 12–20 | Cite as

Spanish consensus for the management of patients with anaplastic cell thyroid carcinoma

  • P. Jiménez-FonsecaEmail author
  • J. M. Gómez Saez
  • J. Santamaria Sandi
  • J. Capdevila
  • E. Navarro Gonzalez
  • C. Zafon Llopis
  • T. Ramón y Cajal Asensio
  • G. Riesco-Eizaguirre
  • E. Grande
  • J. C. Galofré
Review Article

Abstract

Anaplastic thyroid cancer (ATC) is the most aggressive solid tumor and almost uniformly lethal in humans. The Boards of the Thyroid Cancer Group of the Spanish Society of Endocrinology and Nutrition and the Grupo Español de Enfermedades Huérfanas e Infrecuentes of the Spanish Society of Oncology requested that an independent task force draft a more comprehensive consensus statement regarding ATC. All relevant literature was reviewed, including serial PubMed searches together with additional articles. This is the first, comprehensive Spanish consensus statement for ATC and includes the characteristics, diagnosis, initial evaluation, treatment goals, recommendations and modalities for locoregional and advanced disease, palliative care options, surveillance, and long-term monitoring. Newer systemic therapies are being investigated, but more effective combinations are needed to improve patient outcomes. Though more aggressive radiotherapy has reduced locoregional recurrences, median overall survival has not improved in more than 50 years.

Keywords

Anaplastic thyroid carcinoma Poorly differentiated thyroid carcinoma Genetic abnormalities Distant metastases 

Notes

Acknowledgments

The Board of the Thyroid Cancer Group of the Spanish Society of Endocrinology and Nutrition (SEEN) and the GETHI (Grupo Español de Enfermedades Huérfanas e Infrecuentes) of the Spanish Society of Oncology (SEOM) staff whose support made this review possible.

Conflict of interest

The authors have nothing to disclose.

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Copyright information

© Federación de Sociedades Españolas de Oncología (FESEO) 2016

Authors and Affiliations

  • P. Jiménez-Fonseca
    • 1
    Email author
  • J. M. Gómez Saez
    • 2
  • J. Santamaria Sandi
    • 3
  • J. Capdevila
    • 4
  • E. Navarro Gonzalez
    • 5
  • C. Zafon Llopis
    • 6
  • T. Ramón y Cajal Asensio
    • 7
  • G. Riesco-Eizaguirre
    • 8
  • E. Grande
    • 9
  • J. C. Galofré
    • 10
  1. 1.Medical Oncology ServiceHospital Universitario Central de AsturiasOviedoSpain
  2. 2.CIBERDEM, Endocrinology and Nutrition ServiceHospital Universitario de BellvitgeBarcelonaSpain
  3. 3.Endocrinology and Nutrition ServiceHospital Universitario de CrucesVizcayaSpain
  4. 4.Medical Oncology ServiceHospital Universitario de la Vall d’HebronBarcelonaSpain
  5. 5.Endocrinology and Nutrition ServiceHospital Universitario Virgen del RocioSevillaSpain
  6. 6.Endocrinology and Nutrition ServiceHospital Universitario de la Vall d’HebronBarcelonaSpain
  7. 7.Medical Oncology ServiceHospital de la Santa Creu i Sant PauBarcelonaSpain
  8. 8.Endocrinology and Nutrition ServiceHospital Universitario de MóstolesMadridSpain
  9. 9.Medical Oncology ServiceHospital Universitario Ramón y CajalMadridSpain
  10. 10.Endocrinology and Nutrition ServiceClínica Universidad de NavarraPamplonaSpain

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