Clinical and Translational Oncology

, Volume 18, Issue 8, pp 769–775 | Cite as

Consensus on management of advanced medullary thyroid carcinoma on behalf of the Working Group of Thyroid Cancer of the Spanish Society of Endocrinology (SEEN) and the Spanish Task Force Group for Orphan and Infrequent Tumors (GETHI)

  • E. GrandeEmail author
  • J. Santamaría Sandi
  • J. Capdevila
  • E. Navarro González
  • C. Zafón Llopis
  • T. Ramón y Cajal Asensio
  • J. M. Gómez Sáez
  • P. Jiménez-Fonseca
  • G. Riesco-Eizaguirre
  • J. C. Galofré
Review Article



Of all thyroid cancers, <5 % are medullary (MTC). It is a well-characterized neuroendocrine tumor arising from calcitonin-secreting C cells, and RET gene plays a central role on its pathogeny.


The electronic search was conducted using MEDLINE (PubMed), EMBASE and Cochrane Central Register of Controlled Trials. Quality assessments of selected current articles, guidelines and reviews of MTC were performed.


This consensus updates and summarizes biology, treatment and prognostic considerations of MTC.


Multidisciplinary teams and specialized centers are recommended for the management of MTC patients. In the metastatic setting, those patients with large volume of disease are candidates to start systemic treatment mainly if they are symptomatic and the tumor has progressed in the last 12–14 months. Wait and see strategy should be offered to patients with: disseminated disease with only high levels of calcitonin and no macroscopic structural disease, low burden and absence of progression.


Cabozantinib Calcitonin Carcinoembryonic antigen Medullary thyroid carcinoma Thyroid cancer Review Vandetanib 


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Copyright information

© Federación de Sociedades Españolas de Oncología (FESEO) 2015

Authors and Affiliations

  • E. Grande
    • 1
    Email author
  • J. Santamaría Sandi
    • 2
  • J. Capdevila
    • 3
  • E. Navarro González
    • 4
  • C. Zafón Llopis
    • 5
  • T. Ramón y Cajal Asensio
    • 6
  • J. M. Gómez Sáez
    • 7
  • P. Jiménez-Fonseca
    • 8
  • G. Riesco-Eizaguirre
    • 9
  • J. C. Galofré
    • 10
  1. 1.Servicio de Oncología MédicaHospital Ramón y CajalMadridSpain
  2. 2.Endocrinology and Nutrition ServiceHospital Universitario de CrucesVizcayaSpain
  3. 3.Medical Oncology ServiceHospital Universitario Vall d’HebronBarcelonaSpain
  4. 4.Endocrinology and Nutrition ServiceHospital Universitario Virgen del RocioSevilleSpain
  5. 5.Endocrinology and Nutrition ServiceHospital Universitario Vall d’HebronBarcelonaSpain
  6. 6.Medical Oncology ServiceHospital de la Santa Creu i Sant PauBarcelonaSpain
  7. 7.CIBERDEM, Endocrinology and Nutrition ServiceHospital Universitario de BellvitgeBarcelonaSpain
  8. 8.Medical Oncology ServiceHospital Universitario Central de AsturiasOviedoSpain
  9. 9.Endocrinology and Nutrition ServiceHospital Universitario de MóstolesMadridSpain
  10. 10.Endocrinology and Nutrition ServiceClínica Universidad de NavarraPamplonaSpain

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