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ATAD2 is overexpressed in gastric cancer and serves as an independent poor prognostic biomarker

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Abstract

Objective

ATPase family, AAA domain containing 2 (ATAD2) has been found overexpressed in various cancer types and correlated with malignant status and poor prognosis. However, little is known about the clinical significance of ATAD2 in gastric cancer patients. The aim of this study was to explore the clinical and prognostic significance of ATAD2 in gastric cancer.

Methods

The mRNA and protein levels expression of ATAD2 were detected in clinical tissue samples by qRT-PCR and immunohistochemistry, respectively. We examined the ATAD2 protein expression by immunohistochemistry. Furthermore, we analyzed the association between ATAD2 expression and clinicopathological features including prognosis in 166 gastric cancer samples.

Results

In our results, ATAD2 mRNA and protein were highly expressed in gastric cancer samples. ATAD2 overexpression was correlated with advanced clinical stage, tumor depth, lymph node metastasis, and distant metastasis. According to the survival analysis, ATAD2 protein overexpression was a poor independent prognostic factor for gastric cancer patients.

Conclusions

In summary, ATAD2 could serve as a prognostic biomarker for gastric cancer patients.

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Authors and Affiliations

  1. Department of Gastroenterology, Shandong Provincial Qianfoshan Hospital, Shandong University, No.16766 Jingshi Road, Jinan, 250014, China

    M.- J. Zhang, C.- Z. Zhang, W.- J. Du, X.- Z. Yang & Z.- P. Chen

Authors
  1. M.- J. Zhang
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  2. C.- Z. Zhang
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  3. W.- J. Du
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  4. X.- Z. Yang
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  5. Z.- P. Chen
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Corresponding author

Correspondence to Z.- P. Chen.

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The authors declare that they have no conflict of interests.

Ethical approval

All procedures performed in studies involving human participants were in accordance with Research Ethics Committee of Shandong Provincial Qianfoshan Hospital and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Zhang, M.J., Zhang, C.Z., Du, W.J. et al. ATAD2 is overexpressed in gastric cancer and serves as an independent poor prognostic biomarker. Clin Transl Oncol 18, 776–781 (2016). https://doi.org/10.1007/s12094-015-1430-8

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  • DOI: https://doi.org/10.1007/s12094-015-1430-8

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