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Clinical and Translational Oncology

, Volume 18, Issue 5, pp 427–436 | Cite as

Non-coding RNAs deregulation in oral squamous cell carcinoma: advances and challenges

  • T. YuEmail author
  • C. Li
  • Z. Wang
  • K. Liu
  • C. Xu
  • Q. Yang
  • Y. Tang
  • Y. WuEmail author
Review Article

Abstract

Oral squamous cell carcinoma (OSCC) is a common cause of cancer death. Despite decades of improvements in exploring new treatments and considerable advance in multimodality treatment, satisfactory curative rates have not yet been reached. The difficulty of early diagnosis and the high prevalence of metastasis associated with OSCC contribute to its dismal prognosis. In the last few decades the emerging data from both tumor biology and clinical trials led to growing interest in the research for predictive biomarkers. Non-coding RNAs (ncRNAs) are promising biomarkers. Among numerous kinds of ncRNAs, short ncRNAs, such as microRNAs (miRNAs), have been extensively investigated with regard to their biogenesis, function, and importance in carcinogenesis. In contrast to miRNAs, long non-coding RNAs (lncRNAs) are much less known concerning their functions in human cancers especially in OSCC. The present review highlighted the roles of miRNAs and newly discovered lncRNAs in oral tumorigenesis, metastasis, and their clinical implication.

Keywords

Non-coding RNAs microRNAs Long non-coding RNAs Oral squamous cell carcinoma 

Notes

Acknowledgments

This paper was supported by the Fund of the Department of Science and Technology of Sichuan Province (grant no. 2014JY0033) and Fund of the Sichuan Provincial Bureau of Health (grant no. 130231).

Compliance with ethical standards

Informed consent

All authors are in agreement with the content of this manuscript and gave their informed consent prior to their inclusion in this study.

Conflict of interest

There were no human participants and/or animal experiments in this review. So, there is no conflict of interest in this study.

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Copyright information

© Federación de Sociedades Españolas de Oncología (FESEO) 2015

Authors and Affiliations

  1. 1.Department of Head and Neck Oncology SurgerySichuan Cancer HospitalChengduPeople’s Republic of China
  2. 2.State Key Laboratory of Oral Diseases, West China School of StomatologySichuan UniversityChengduPeople’s Republic of China

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