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Epstein–Barr virus-encoded small RNA 1 (EBER-1) could predict good prognosis in nasopharyngeal carcinoma

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EBER-1 (a non-coding RNA transcribed by EBV) expression was detected in most of Epstein–Barr virus (EBV)-positive nasopharyngeal carcinoma (NPC) patients. However, the relevance between EBER-1 expression and NPC clinical outcome has not been reported. This study aims to assess the possible correlations of EBER-1 expression and clinical parameters and its potential prognostic predictive ability in NPC patient’s outcomes.


We examined EBER-1 mRNA expression in 301 NPC and 130 non-NPC tissues using in situ hybridization and did statistics.


EBER-1 expression was up-regulated in NPC tissues when compared to non-NPC tissues. A receiver operating characteristic analysis revealed that EBER-1 expression could distinguish non-cancerous patients from NPC patients (p < 0.001, sensitivity: 72.5 %, specificity: 83.5 %, AUC = 0.815). A survival analysis revealed that patients with high levels of EBER-1 expression had a significantly good prognosis (Disease-free survival: p = 0.019, overall survival: p = 0.006).


These results indicated that EBER-1 expression is a potential prognosis factor of NPC and highly negative correlated with the progress of NPC.

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This work was supported by the National Natural Science Foundation of China (Grant Nos. 81172189, 81272298, 81372907, 81472531 and 91229122), the Hunan Province Natural Science Foundation of China (Grant Nos. 14JJ1010, 12JJ2044), the Hunan Province Science and Technology Foundation of China (Grant No. 2012FJ6073).

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Correspondence to W. Zhang or G. Li.

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Before study initiation, ethical approval was obtained from Xiangya Hospital in Changsha, and the Central South University Ethics Review Committees/Institutional Review Boards. NPC samples, non-tumor nasopharyngeal epithelial tissues were collected at Xiangya Hospital. All of the individuals participating in this project gave informed consent, and the study was approved by the Xiangya Medical Ethics Board.

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Zeng, Z., Fan, S., Zhang, X. et al. Epstein–Barr virus-encoded small RNA 1 (EBER-1) could predict good prognosis in nasopharyngeal carcinoma. Clin Transl Oncol 18, 206–211 (2016).

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