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Obesity as a risk factor in cancer: A national consensus of the Spanish Society for the Study of Obesity and the Spanish Society of Medical Oncology

Clinical and Translational Oncology volume 17, pages 763–771 (2015)Cite this article

Abstract

In the last few years, many prospective studies have demonstrated a clear association between obesity and cancers of the colon and rectum, breast in post-menopausal women, endometrium, kidney, oesophagus and pancreas. Obesity is also associated with a high risk of recurrence and cancer-related death. The pathophysiology of obesity involves various changes that may be implicated in the relationship between obesity and cancer, such as excess inflammatory cytokines and chronic inflammation, hyperinsulinaemia, insulin resistance, and raised leptin and oestrogens. The Spanish Society for the Study of Obesity and the Spanish Society of Medical Oncology have signed a cooperation agreement to work together towards reducing the impact of obesity in cancer. Preventing obesity prevents cancer.

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Acknowledgments

The authors are grateful for the editorial assistance of Ana Martín of HealthCo (Madrid, Spain) in the production of this manuscript.

Conflict of interest

The authors declare that, when writing and revising the text, they did not know the names of the pharmaceutical companies that provided financial support for this project, so this support has not influenced the content of this article.

Ethical statement

The study has been performed in accordance with the ethical standards of the Declaration of Helsinki and its later amendments. This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent statement

Additional informed consent was obtained from all individual participants for whom identifying information is included in this article.

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Affiliations

  1. Servicio de Endocrinología, Hospital del Mar, Passeig Marítim de la Barceloneta 25-29, 08003, Barcelona, Spain

    A. Goday

  2. IMIM Institut Mar de Investigacions Mediques, CiberOBN, Passeig Marítim de la Barceloneta 25-29, 08003, Barcelona, Spain

    A. Goday

  3. Servicio de Oncología Médica, Hospital Universitario Reina Sofía, Córdoba, Spain

    I. Barneto

  4. Servicio de Endocrinología, Hospital Universitario Virgen de la Victoria, Málaga, Spain

    J. M. García-Almeida

  5. Servicio de Oncología Médica, Consorcio Hospital General Universitario de Valencia, Valencia, Spain

    A. Blasco

  6. Servicio de Endocrinología, Hospital Arnau de Vilanova, Lleida, Spain

    A. Lecube

  7. Servicio de Oncología Médica, Hospital Universitario 12 de Octubre, Madrid, Spain

    C. Grávalos

  8. Servicio de Endocrinología, Hospital Universitario Severo Ochoa, Leganés, Madrid, Spain

    P. Martínez de Icaya

  9. Servicio de Oncología Médica, Consorcio Hospitalario Provincial de Castellón, Castelló de la Plana, Castellón, Spain

    R. de las Peñas

  10. Servicio de Endocrinología, Hospital General Universitario Gregorio Marañón, Madrid, Spain

    S. Monereo

  11. Servicio de Oncología Médica, Complejo Hospitalario de Pontevedra, Pontevedra, Spain

    L. Vázquez

  12. Servicio de Endocrinología, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Tenerife, Spain

    J. E. Palacio

  13. Servicio de Oncología Médica, Hospital Clínico Universitario San Carlos, Madrid, Spain

    P. Pérez-Segura

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  1. A. Goday
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Goday, A., Barneto, I., García-Almeida, J.M. et al. Obesity as a risk factor in cancer: A national consensus of the Spanish Society for the Study of Obesity and the Spanish Society of Medical Oncology. Clin Transl Oncol 17, 763–771 (2015). https://doi.org/10.1007/s12094-015-1306-y

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Keywords

  • Fatty acids
  • Adipokines
  • Inflammatory cytokines
  • IGF1 and 2
  • BMI
  • Insulin