Skip to main content
SpringerLink
Log in

Association of ERCC1 polymorphisms (rs3212986 and rs11615) with the risk of head and neck carcinomas based on case–control studies

  • Research Article
  • Published:
Clinical and Translational Oncology Aims and scope Submit manuscript

Abstract

Purpose

Current data regarding association between ERCC1 polymorphisms and the risk of head and neck squamous cell carcinomas (HNSCC) have shown controversial results. The current study aims to achieve a more accurate estimation of the association between two well-characterized ERCC1 polymorphisms (rs3212986 and rs11615) and HNSCC risk by a meta-analysis of all eligible studies.

Methods

The meta-analysis was performed by reviewing seven studies on the ERCC1 C8092A (rs3212986) polymorphism including 2055 cases and 2635 controls and four studies on the T19007C (rs11615) polymorphism including 910 cases and 1337 controls.

Results

For ERCC1 rs3212986 polymorphism, no significant association with HNSCC was found in overall analysis, but subgroup analysis revealed that a significant association of the rs3212986 polymorphism was found among Asians (A vs. C: OR 0.83; 95 % CI 0.70–0.99) but not Caucasians. For ERCC1 rs11615 polymorphism, a significant association with HNSCC (TC + CC vs. TT: OR 1.23; 95 % CI 1.03–1.47) was found in overall analysis. Consistently, subgroup analysis revealed that significant associations of the rs3212986 polymorphism were found among Asians (C vs. T: OR 1.32; 95 % CI 1.04–1.69) and in laryngeal carcinoma (CC vs. TC + TT: OR 1.32; 95 % CI 1.02–1.72).

Conclusion

The findings of the meta-analysis indicated that a decreased risk for the ERCC1 rs3212986 polymorphism was found among Asians, and an increased risk for the ERCC1 rs11615 polymorphism was found in overall HNSCC, especially in Asian subgroup and laryngeal site, suggesting that ERCC1 rs3212986 polymorphism in Asians may act as a protective factor and rs11615 polymorphism may be a risk factor for HNSCC.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin. 2012;62:10–29.

    Article  PubMed  Google Scholar 

  2. Marron M, Boffetta P, Zhang ZF, Zaridze D, Wunsch-Filho V, Winn DM, et al. Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk. Int J Epidemiol. 2010;39:182–96.

    Article  PubMed Central  PubMed  Google Scholar 

  3. Leemans CR, Braakhuis BJ, Brakenhoff RH. The molecular biology of head and neck cancer. Nat Rev Cancer. 2011;11:9–22.

    Article  CAS  PubMed  Google Scholar 

  4. Lacko M, Braakhuis BJ, Sturgis EM, Boedeker CC, Suárez C, Rinaldo A, et al. Genetic susceptibility to head and neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2014;89:38–48.

    Article  CAS  PubMed  Google Scholar 

  5. Wan D, Gu W, Xu G, Shen C, Ding D, Shen S, et al. Effects of common polymorphisms rs2910164 in miR-146a and rs11614913 in miR-196a2 on susceptibility to colorectal cancer: a systematic review meta-analysis. Clin Transl Oncol. 2014;16:792–800.

    Article  CAS  PubMed  Google Scholar 

  6. Guo XP, Wang Y, Zhao H, Song SD, Zhou J, Han Y. Association of MTHFR C677T polymorphisms and colorectal cancer risk in Asians: evidence of 12,255 subjects. Clin Transl Oncol. 2014;16:623–9.

    Article  CAS  PubMed  Google Scholar 

  7. van Duin M, de Wit J, Odijk H, Westerveld A, Yasui A, Koken MH, et al. Molecular characterization of the human excision repair gene ERCC-1: cDNA cloning and amino acid homology with the yeast DNA repair gene RAD10. Cell. 1986;44:913–23.

    Article  PubMed  Google Scholar 

  8. Zhang L, Wang J, Xu L, Zhou J, Guan X, Jiang F, et al. Nucleotide excision repair gene ERCC1 polymorphisms contribute to cancer susceptibility: a meta-analysis. Mutagenesis. 2012;27:67–76.

    Article  CAS  PubMed  Google Scholar 

  9. Xin Y, Hao S, Lu J, Wang Q, Zhang L. Association of ERCC1 C8092A and ERCC2 Lys751Gln polymorphisms with the risk of glioma: a meta-analysis. PLoS ONE. 2014;9:e95966.

    Article  PubMed Central  PubMed  Google Scholar 

  10. Zhu J, Hua RX, Jiang J, Zhao LQ, Sun X, Luan J, et al. Association studies of ERCC1 polymorphisms with lung cancer susceptibility: a systematic review and meta-analysis. PLoS One. 2014;9:e97616.

    Article  PubMed Central  PubMed  Google Scholar 

  11. Sturgis EM, Dahlstrom KR, Spitz MR, Wei Q. DNA repair gene ERCC1 and ERCC2/XPD polymorphisms and risk of squamous cell carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg. 2002;128:1084–8.

    Article  PubMed  Google Scholar 

  12. Sugimura T, Kumimoto H, Tohnai I, Fukui T, Matsuo K, Tsurusako S, et al. Gene-environment interaction involved in oral carcinogenesis: molecular epidemiological study for metabolic and DNA repair gene polymorphisms. J Oral Pathol Med. 2006;35:11–8.

    Article  CAS  PubMed  Google Scholar 

  13. Yang M, Kim WH, Choi Y, Lee SH, Kim KR, Lee HS, et al. Effects of ERCC1 expression in peripheral blood on the risk of head and neck cancer. Eur J Cancer Prev. 2006;15:269–73.

    Article  CAS  PubMed  Google Scholar 

  14. An J, Liu Z, Hu Z, Li G, Wang LE, Sturgis EM, et al. Potentially functional single nucleotide polymorphisms in the core nucleotide excision repair genes and risk of squamous cell carcinoma of the head and neck. Cancer Epidemiol Biomark Prev. 2007;16:1633–8.

    Article  CAS  Google Scholar 

  15. Abbasi R, Ramroth H, Becher H, Dietz A, Schmezer P, Popanda O. Laryngeal cancer risk associated with smoking and alcohol consumption is modified by genetic polymorphisms in ERCC5, ERCC6 and RAD23B but not by polymorphisms in five other nucleotide excision repair genes. Int J Cancer. 2009;125:1431–9.

    Article  CAS  PubMed  Google Scholar 

  16. Yang ZH, Dai Q, Kong XL, Yang WL, Zhang L. Association of ERCC1 polymorphisms and susceptibility to nasopharyngeal carcinoma. Mol Carcinog. 2009;48:196–201.

    Article  CAS  PubMed  Google Scholar 

  17. Li X, Xu J, Yang X, Wu Y, Cheng B, Chen D, Bai B. Association of single nucleotide polymorphisms of nucleotide excision repair genes with laryngeal cancer risk and interaction with cigarette smoking and alcohol drinking. Tumour Biol. 2014;35:4659–65.

    Article  CAS  PubMed  Google Scholar 

  18. Lu B, Li J, Gao Q, Yu W, Yang Q, Li X. Laryngeal cancer risk and common single nucleotide polymorphisms in nucleotide excision repair pathway genes ERCC1, ERCC2, ERCC3, ERCC4, ERCC5 and XPA. Gene. 2014;542:64–8.

    Article  CAS  PubMed  Google Scholar 

  19. Jones NR, Spratt TE, Berg AS, Muscat JE, Lazarus P, Gallagher CJ. Association studies of excision repair cross-complementation group 1 (ERCC1) haplotypes with lung and head and neck cancer risk in a Caucasian population. Cancer Epidemiol. 2011;35:175–81.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  20. Matullo G, Dunning AM, Guarrera S, Baynes C, Polidoro S, Garte S, et al. DNA repair polymorphisms and cancer risk in non-smokers in a cohort study. Carcinogenesis. 2006;27:997–1007.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported by the National Natural Science Foundation of China (Grant Nos. 81400513, 81470736, 81302358, and 81202132), the Science and Technology Commission of Shanghai (Grant No. 14401931600).

Conflict of interest

The authors have declared no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Stomatology, Affiliated Cixi People’s Hospital, Wenzhou Medical University, Wenzhou, China

    Y. W. Ding

  2. Department of Oral and Maxillofacial Surgery, XiangYa Hospital, Central South University, Changsha, Hunan, China

    X. Gao

  3. Shanghai Key Laboratory of Stomatology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

    D. X. Ye, W. Liu & L. Wu

  4. Department of Stomatology, Huashan Hospital, Fudan University, Shanghai, China

    H. Y. Sun

Authors
  1. Y. W. Ding
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. X. Gao
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. X. Ye
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. W. Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. L. Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. H. Y. Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to L. Wu or H. Y. Sun.

Additional information

Y. W. Ding and X. Gao contributed equally to this work.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ding, Y.W., Gao, X., Ye, D.X. et al. Association of ERCC1 polymorphisms (rs3212986 and rs11615) with the risk of head and neck carcinomas based on case–control studies. Clin Transl Oncol 17, 710–719 (2015). https://doi.org/10.1007/s12094-015-1298-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12094-015-1298-7

Keywords

Search

Navigation