Clinical and Translational Oncology

, Volume 16, Issue 3, pp 234–242 | Cite as

Recommendations of a group of experts for the pathological assessment of tumour regression of liver metastases of colorectal cancer and damage of non-tumour liver tissue after neoadjuvant therapy

  • M. L. Gómez DorronsoroEmail author
  • R. Vera
  • L. Ortega
  • C. Plaza
  • R. Miquel
  • M. García
  • E. Díaz
  • M. R. Ortiz
  • J. Pérez
  • C. Hörndler
  • C. Villar
  • J. Antúnez
  • S. Pereira
  • F. López-Rios
  • R. González-Cámpora
Educational Series - Red Series New Trends in Clinical Oncology


Colorectal cancer (CRC) incidence has increased during the past decades in Spain, being the first malignant tumour in incidence. Observed mortality for CRC is mainly due to liver and lung metastases. The only curative treatment is surgery; new surgical techniques and neoadjuvant treatments have increased the number of surgery candidate patients. Patients should be managed with a multidisciplinary approach that includes imaging techniques, chemotherapy, surgery and pathological assessment. As an answer to this approach, a group of pathology experts interested on CRC liver metastases aimed to review the diagnosis and prognosis of liver mestastases and developed practical recommendations for its assessment. The expert group revised the current literature and prepared questions to be discussed based on available evidence and on their clinical practise. As a result, recommendations for the assessment of tumour regression of liver metastases are proposed, which could be implemented in oncology centres allowing assessment standardisation for these patients. Prospective multi-center studies to evaluate these recommendations validity will further contribute to improve the standard care of CRC liver metastases patients.


Recommendation Colorectal cancer Liver metastases Pathological response Tumour regression grade 



The authors would like to thank Eliana Mesa who has provided medical writing assistance on behalf of Springer Healthcare. The necessary scientific meetings along with medical writing services were supported financially by Roche Farma, S.A. of Spain. Roche Farma, S.A. of Spain has not had any influence on the manuscript content.

Conflict of interest

María Rosa Ortiz Duran and Esther Díaz Gómez have received clinical study grants from Roche Farma S.A. of Spain, Ricardo González-Cámpora has participated on studies supported by Novartis. All other authors declare that they do not have any conflict of interest that may inappropriately influence this work.


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Copyright information

© Federación de Sociedades Españolas de Oncología (FESEO) 2013

Authors and Affiliations

  • M. L. Gómez Dorronsoro
    • 1
    Email author
  • R. Vera
    • 2
  • L. Ortega
    • 3
  • C. Plaza
    • 4
  • R. Miquel
    • 5
  • M. García
    • 6
  • E. Díaz
    • 7
  • M. R. Ortiz
    • 7
  • J. Pérez
    • 8
  • C. Hörndler
    • 9
  • C. Villar
    • 10
  • J. Antúnez
    • 11
  • S. Pereira
    • 12
  • F. López-Rios
    • 4
  • R. González-Cámpora
    • 12
  1. 1.Servicio de Anatomía Patológica, Hospital de NavarraPamplonaSpain
  2. 2.Departamento de OncologíaHospital de NavarraPamplonaSpain
  3. 3.Servicio de Anatomía Patológica, Hospital Clínico San CarlosMadridSpain
  4. 4.Laboratorio de Dianas Terapéuticas, Centro Integral Oncológico “Clara Campal”, Hospital HM Universitario SanchinarroMadridSpain
  5. 5.Servicio de Anatomía Patológica, Hospital Clínic de BarcelonaBarcelonaSpain
  6. 6.Servicio de Anatomía Patológica, Hospital del MarBarcelonaSpain
  7. 7.Servicio de Anatomía Patológica, Hospital de Girona Dr Josep TruetaGironaSpain
  8. 8.Servicio de Anatomía Patológica, Hospital Universitario la FeValenciaSpain
  9. 9.Departamento de Anatomía PatologíaHospital Miguel ServetZaragozaSpain
  10. 10.Servicio de Anatomía Patológica. Hospital Universitario Reina SofíaCórdobaSpain
  11. 11.Servicio de Anatomía Patológica, Complejo Hospitalario Universitario de Santiago de CompostelaSantiago de CompostelaSpain
  12. 12.Departamento de Anatomía PatológicaHospital Universitario Virgen MacarenaSevillaSpain

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