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Clinical and Translational Oncology

, Volume 15, Issue 3, pp 248–251 | Cite as

DeCIDE and PARADIGM: nails in the coffin of induction chemotherapy in head and neck squamous cell carcinoma?

  • S. W. LooEmail author
  • K. Geropantas
  • T. W. Roques
Correspondence

Induction chemotherapy was first used in squamous cell carcinoma of the head and neck (SCCHN) in the 1970s. High overall response rates were observed in previously untreated tumours [1] and a correlation between response to induction chemotherapy and favourable outcome following radiotherapy was noted [2]. Numerous subsequent randomised studies and meta-analyses nonetheless failed to demonstrate a significant survival advantage with the use of induction chemotherapy compared with locoregional treatment alone [3]. A marginally significant 5 % absolute improvement in 5 year survival was seen when analysis was restricted to studies using a platin and 5-fluorouracil (PF) as the induction regimen. This was however overshadowed by the larger survival benefit observed with concurrent chemoradiation (CRT). As a result, CRT became widely accepted as the standard of care in the non-surgical management of patients with locoregionally advanced SCCHN.

Recent years have witnessed a renewed interest...

Keywords

Docetaxel Induction Chemotherapy DeCIDE Trial Slow Accrual Advanced Nodal Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Conflict of interest

None.

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Copyright information

© Federación de Sociedades Españolas de Oncología (FESEO) 2012

Authors and Affiliations

  1. 1.Department of OncologyNorfolk and Norwich University HospitalNorwichUK

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