Abstract
Annexin family proteins are a well-known multigene family of Ca2+-regulated phospholipid- and membrane-binding proteins. As one of the annexin family genes/proteins, accumulated researches have begun to reveal that annexin A3 (Anxa3) exhibits important roles in tumor development, metastasis and drug resistance. The summarized research evidences in recent years indicate Anxa3 might specifically functionalize either as a tumor suppressor or as a tumor promoter candidate for different cancers depending on the types of tumor cells and tissues. The up-regulation of Anxa3 was found to be correlated with enhanced drug resistance of ovarian cancer, to promote the developments of colorectal adenocarcinoma and pancreatic carcinoma, and to facilitate the metastases of lung adenocarcinoma and hepatocarcinoma; meanwhile, the decreased Anxa3 expressions was negatively correlated with the developments of prostatic carcinoma and renal carcinoma. It is conceivable that Anxa3 could be regarded as a target for therapeutic intervention and a biological indicator for tumor development, invasion and metastasis as well as for the prognosis of tumor patients.
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This research was supported by grants from National Natural Science Foundation of China (81050010; 81171957) and Key Laboratory of Department of Education of Liaoning (LS2010050). We thank Prof. Frederick Greenaway at Clark University, USA for reading the manuscript and editing the English of the manuscript.
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Na Wu and Shuqing Liu contributed equally as the first author.
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Wu, N., Liu, S., Guo, C. et al. The role of annexin A3 playing in cancers. Clin Transl Oncol 15, 106–110 (2013). https://doi.org/10.1007/s12094-012-0928-6
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DOI: https://doi.org/10.1007/s12094-012-0928-6