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BIK/NBK gene as potential marker of prognostic and therapeutic target in breast cancer patients

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Abstract

Purpose

The purpose of this study is to determine the association between the BIK/NBK gene expression and estrogen receptor alpha expression.

Materials and methods

We determined the association of BIK/NBK gene expression by real time quantitative reverse transcription polymerase chain reaction and estrogen receptor alpha expression by immunohistochemistry in samples of breast cancer tissue.

Results

We found a statistically significant correlation of BIK/NBK gene expression with the estrogen receptor alpha expression (ρ = 0.751, p = 0.004). For verify differences of BIK/NBK gene expression among ERα+ and ERα− breast cancer tissues, Mann–Whitney U test was performed, obtaining significant differences.

Conclusions

BIK/NBK gene expression may have important clinical implications and provide predictive, prognostic or therapeutic marker in breast cancer patients according to the estrogen receptor alpha expression.

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Acknowledgments

This work was supported by Grants No. 2007-785-063 from FIS (Fondo de Investigación en Salud).

Conflict of interest

The authors declare that they have no competing interests.

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Authors and Affiliations

  1. Unidad de Investigación Médica en Genética Humana, Hospital de Pediatría, Centro Médico Nacional Siglo XXI (CMN S-XXI), Instituto Mexicano del Seguro Social (IMSS), Av. Cuauhtémoc 330, Col. Doctores, Del. Cuauhtémoc, CP 06720, Mexico D.F., Mexico

    Eunice López-Muñoz, Adelina Hernández-Zarco, Normand García-Hernández & Diego Arenas-Aranda

  2. Servicio de Patología, Hospital de Oncología, CMN-SXXI, IMSS, Av. Cuauhtémoc 330, Col. Doctores, Del. Cuauhtémoc, CP 06720, Mexico, D.F., Mexico

    Isabel Alvarado-Cabrero

  3. Servicio de Tumores de mama, Hospital de Oncología, CMN S-XXI, IMSS, Av. Cuauhtémoc 330, Col. Doctores, Del. Cuauhtémoc, CP 06720, Mexico, D.F., Mexico

    Gelasio Zarco-Espinosa

  4. Coordinación de Investigación en salud, IMSS, Av. Cuauhtémoc 330, Col. Doctores, Del. Cuauhtémoc, CP 06720, Mexico, D.F., Mexico

    Fabio Salamanca-Gómez

Authors
  1. Eunice López-Muñoz
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  2. Adelina Hernández-Zarco
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  3. Normand García-Hernández
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  4. Isabel Alvarado-Cabrero
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  5. Gelasio Zarco-Espinosa
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  6. Fabio Salamanca-Gómez
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Corresponding author

Correspondence to Eunice López-Muñoz.

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López-Muñoz, E., Hernández-Zarco, A., García-Hernández, N. et al. BIK/NBK gene as potential marker of prognostic and therapeutic target in breast cancer patients. Clin Transl Oncol 14, 586–591 (2012). https://doi.org/10.1007/s12094-012-0845-8

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  • DOI: https://doi.org/10.1007/s12094-012-0845-8

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