Clinical and Translational Oncology

, Volume 14, Issue 6, pp 413–422 | Cite as

Chemotherapy-induced nausea and vomiting: pathophysiology and therapeutic principles

  • Juan BayoEmail author
  • Paula J. Fonseca
  • Susana Hernando
  • Sonia Servitja
  • Aitana Calvo
  • Sandra Falagan
  • Estefanía García
  • Iria González
  • María José de Miguel
  • Quionia Pérez
  • Ana Milena
  • Antonio Ruiz
  • Agustí Barnadas
Educational Series New Trends in Clinical Oncology


Chemotherapy-induced nausea and vomiting (CINV) is a major determinant of quality of life in cancer patients. In addition, the perceptions that oncology professionals have about CINV quite often do not coincide with reality. Antineoplastic agents and their combinations can be categorised according to their emetogenic level, and this categorisation is helpful for classifying the severity of CINV and treating it. All CINV treatment guidelines emphasise the need to administer prophylaxis to patients who receive highly or moderately emetogenic chemotherapy. With the introduction of NK1 receptor antagonists, the control of acute and delayed CINV after highly or moderately emetogenic chemotherapy schedules has improved in the great majority of patients. NK1 receptor antagonists have been demonstrated to improve the control of CINV in all risk subgroups of patients.


Acute emesis Antiemetics Delayed emesis Highly emetogenic chemotherapy Risk factors Moderately emetogenic chemotherapy 


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Copyright information

© FESEO 2012

Authors and Affiliations

  • Juan Bayo
    • 1
    Email author
  • Paula J. Fonseca
    • 2
  • Susana Hernando
    • 3
  • Sonia Servitja
    • 4
  • Aitana Calvo
    • 5
  • Sandra Falagan
    • 3
  • Estefanía García
    • 6
  • Iria González
    • 4
  • María José de Miguel
    • 7
  • Quionia Pérez
    • 2
  • Ana Milena
    • 8
  • Antonio Ruiz
    • 1
  • Agustí Barnadas
    • 9
  1. 1.Servicio de Oncología MédicaHospital Juan Ramón JiménezHuelvaSpain
  2. 2.Hospital Universitario Central de AsturiasOviedo, AsturiasSpain
  3. 3.Fundación Hospital de AlcorcónAlcorcón, MadridSpain
  4. 4.Hospital del MarBarcelonaSpain
  5. 5.Hospital de la PrincesaMadridSpain
  6. 6.Corporació Sanitària i Universitària Parc TaulíSabadell, BarcelonaSpain
  7. 7.Hospital Universitario Virgen del RocíoSevillaSpain
  8. 8.Hospital Universitario A CoruñaA CoruñaSpain
  9. 9.Hospital de la Santa Creu i Sant PauBarcelonaSpain

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