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Circulating tumour cells in peripheral blood: potential impact on breast cancer outcome

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Abstract

Introduction

In breast cancer, the metastatic process may involve the dissemination of circulating tumour cells (CTCs) through the blood and lymphatic system prior to the colonisation of distant organs. Here we demonstrate the predictive capacity of CTCs for detecting risk of death in breast cancer patients during established time intervals.

Methods

CTCs were identified by immunocytochemical methods following isolation by selective immunomagnetic cell separation of cytokeratin-positive cells. Serial blood samples from 65 patients were collected at roughly monthly intervals for up to 50 months. Follow-up was conducted at different intervals: 1–5, >5–12, >12–24 and >24–50 months.

Results

Both presence and number of CTCs were correlated to risk of death: patients with CTCs at any time during follow-up had a higher risk of death (p=0.035) than patients without CTCs. Furthermore, during the first 5 months of therapy, patients with >5 CTCs had a higher risk of death than patients with <5 CTCs (p=0.002).

Conclusions

Our results show that the persistence of CTCs after chemotherapy, particularly during the first 5 months, could define a group of patients with a high risk of relapse.

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Authors and Affiliations

  1. Pfizer — Universidad de Granada — Junta de Andalucía, Centre for Genomics and Oncological Research (GENYO), Health Sciences Technologic Park Avda. de la Ilustración, 114, ES-18007, Granada, Spain

    María José Serrano, José Antonio Lorente, Ana Fernández & Jaime Fernández Izquierdo

  2. Department of Health Sciences Faculty of Experimental Sciences, University of Jaén, Jaén, Spain

    María José Serrano & Miguel Delgado Rodríguez

  3. Laboratory of Genetic Identification-UGR Department of Legal Medicine, University of Granada, Granada, Spain

    José Antonio Lorente

  4. Medical Oncology Department, University Hospital, Jaén, Spain

    Mónica Fernández, Capilla de la Torre & Pedro Sánchez Rovira

Authors
  1. María José Serrano
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  2. José Antonio Lorente
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  3. Miguel Delgado Rodríguez
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  4. Ana Fernández
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  5. Mónica Fernández
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  6. Capilla de la Torre
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  7. Jaime Fernández Izquierdo
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  8. Pedro Sánchez Rovira
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Correspondence to María José Serrano.

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Serrano, M.J., Lorente, J.A., Rodríguez, M.D. et al. Circulating tumour cells in peripheral blood: potential impact on breast cancer outcome. Clin Transl Oncol 13, 204–208 (2011). https://doi.org/10.1007/s12094-011-0641-x

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  • DOI: https://doi.org/10.1007/s12094-011-0641-x

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