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Clinical and Translational Oncology

, Volume 12, Issue 9, pp 629–633 | Cite as

Fifty-one Kaposi sarcoma patients

  • Mutlu DoganEmail author
  • Lutfi Dogan
  • Feyyaz Ozdemir
  • Nuriye Yildirim Ozdemir
  • Hasan Senol Coskun
  • Ulku Yalcintas Arslan
  • Guze Ozal
  • Gungor Utkan
  • Ahmet Demirkazik
  • Fazil Aydin
  • Nurullah Zengin
  • Fikri Icli
Research Articles

Abstract

Introduction

Kaposi sarcoma (KS) is a mesenchymal tumor originating from lymphatic endothelial cells. Immunsupressive patients have higher risk for KS. HHV-8 has a role in immunpathogenesis of KS.

Aim

Evaluation of demographical properties with tumor characteristics and treatment modalities of KS.

Material and method

Histopathologically documented KS patients were evaluated retrospectively. Anti-HIV seroprevalence was also evaluated with patient and tumor characteristics besides treatment regimens.

Results

Fifty-one patients were included between September 1998 and February 2009. Male/female ratio was 3.25 (39/12). Median age was 68 (31–94). Lower extremity was the most common site whereas excisional biopsy was the most common diagnostic procedure. Smoking rate was 42.8%. Twenty percent had family history for cancer. Anti-HIV seropositivity rate was 1.9%. Thirty eight percent had local monotherapy, and radiotherapy was most common (26%). Multidisciplinary approach rate was 44%. Most of them had surgery and radiotherapy combination. Two-third of the patients had radiotherapy alone or with other modalities. Rates were as 12% for chemotherapy and 6% for interferon. Vincristine-bleomycin-doxorubicin combination was the most preferred regimen (60%).

Conclusion

Male patients in the sixth decade seem to have higher risk for KS. Smoking rate was almost as high. Local therapy might be sufficient in most of the patients. However, we may also consider systemic chemotherapy for selected patients, including vincristine, bleomycin and doxorubicin.

Keywords

Kaposi sarcoma Treatment of Kaposi sarcoma Chemotherapy in Kaposi sarcoma Interferon in Kaposi sarcoma 

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Copyright information

© Feseo 2010

Authors and Affiliations

  • Mutlu Dogan
    • 1
    Email author
  • Lutfi Dogan
    • 2
  • Feyyaz Ozdemir
    • 3
  • Nuriye Yildirim Ozdemir
    • 4
  • Hasan Senol Coskun
    • 5
  • Ulku Yalcintas Arslan
    • 6
  • Guze Ozal
    • 1
  • Gungor Utkan
    • 1
  • Ahmet Demirkazik
    • 1
  • Fazil Aydin
    • 3
  • Nurullah Zengin
    • 4
  • Fikri Icli
    • 1
  1. 1.Department of Medical Oncology Cebeci HospitalAnkara University School of MedicineDikimevi, AnkaraTurkey
  2. 2.Department of General SurgeryAnkara Oncology Education and Research HospitalAnkaraTurkey
  3. 3.Department of Medical OncologyKaradeniz Technical University School of MedicineTrabzonTurkey
  4. 4.Department of Medical OncologyAnkara Numune Education and Research HospitalAnkaraTurkey
  5. 5.Department of Medical OncologyAkdeniz University School of MedicineAntalyaTurkey
  6. 6.Department of Medical OncologyAnkara Oncology Education and Research HospitalAnkaraTurkey

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