Skip to main content
Log in

Solid ovarian tumours in childhood: a 35-year review in a single institution

  • Research Articles
  • Published:
Clinical and Translational Oncology Aims and scope Submit manuscript

Abstract

Purpose

Solid ovarian tumours are uncommon in childhood. Our aim is to evaluate the outcomes in a single institution over 35 years.

Methods

We reviewed their clinical presentation, management, pathology and outcomes from 1972 to 2007.

Results

Fifty-three patients, with a median age of 9.2 years (range 0.9–14.2), were registered. Common symptoms at presentation were abdominal pain (75.8%) and abdominal mass (57.4%). Histopathological diagnoses were: 26 mature teratoma, 10 immature teratoma, 8 dysgerminoma, 5 granulosa cell tumours, 2 yolk sac tumours, 1 gonadoblastoma and 1 embryonal carcinoma. Staging (FIGO) for malignant/borderline tumours was: 17 stage I, 1 stage II, 8 stage III and 1 stage IV. Unilateral salpingo-oophorectomy was performed in 47 cases. Sixteen patients underwent chemotherapy after surgery (15 with platinum-based regimen) and postoperative radiotherapy was given in 5 cases. Recurrence was observed in 2 patients and one died (stage III immature teratoma) after a second relapse despite multiple chemotherapy, surgery and radiotherapy. Five-year OS and 5-year EFS were 97% and 94% respectively.

Conclusions

Although rare, ovarian tumours must be included in the differential diagnosis of abdominal pain in childhood. Our results confirm their excellent prognosis using conservative surgery and platinum-based chemotherapy. The key point is to maintain excellent outcome while reducing associated morbidity and preserving fertility.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Cushing B, Perlman E, Castleberry RP et al (2007) Germ cell tumors. In: Pizzo PA, Poplack DG (eds) Principles and practice of pediatric oncology, 5th ed. Philadelphia Lippincott-Williams and Wilkins, pp 1117–1138

  2. Mann J, Raafat F, Robinson K et al (2000) The United Kingdom Children’s Cancer Study Group’s Second Germ Cell Tumor Study: carboplatin, etoposide, and bleomycin are effective treatment for children with malignant extracranial germ cell tumors, with acceptable toxicity. J Clin Oncol 18:3809–3818

    CAS  PubMed  Google Scholar 

  3. (1986) Staging announcement: FIGO Cancer Committee. Gynecol Oncol 25:383

  4. Norris HJ, Zirkin HJ, Benson WL (1976) Immature (malignant) teratoma of the ovary. A clinical and pathologic study of 58 cases. Cancer 37:2359–2372

    Article  CAS  PubMed  Google Scholar 

  5. Dehner LP (1986) Gonadal and extragonadal germ cell neoplasms: teratomas in childhood. In: Finegold M, Benington JL (eds) Pathology of neoplasia in children and adults. WB Saunders, Philadelphia, PA, pp 282–312

    Google Scholar 

  6. Saiz A, Fernandez MS, Segarra V et al (1997) Tumores solidos de ovario en la infancia. Cir Pediatr 10:104–107

    Google Scholar 

  7. Backer A, Madern G, Oosterhuis J et al (2006) Ovarian germ cell tumors in children: a clinical study of 66 patients. Pediatr Blood Cancer 46:459–464

    Article  PubMed  Google Scholar 

  8. Akyuz C, Varan A, Buyukpamukcu N et al (2000) Malignant ovarian tumors in children: 22 years of experience at a single institution. J Pediatr Hematol Oncol 22:422–427

    Article  CAS  PubMed  Google Scholar 

  9. Cass D, Hawkins E, Brandt M et al (2001) Surgery for ovarian masses in infants, children and adolescents: 102 consecutive patients treated in a 15-year period. J Pediatr Surg 36:693–699

    Article  CAS  PubMed  Google Scholar 

  10. Brown MF, Hebra A, McGeehin K et al (1993) Ovarian masses in children: a review of 91 cases of malignant and benign masses. J Pediatr Surg 28:939–932

    Article  Google Scholar 

  11. Billmire D, Vinocur C, Rescorla F et al (2004) Outcome and staging evaluation in malignant germcell tumors of the ovary in children and adolescents: an intergroup study. J Pediatr Surg 39:424–429

    Article  CAS  PubMed  Google Scholar 

  12. Baranzelli MC, Bouffet E, Quintana E et al (2000) Non-seminomatous ovarian germ cell tumours in children. Eur J Cancer 36:376–383

    Article  CAS  PubMed  Google Scholar 

  13. Cabezali D, Cano I, Garcia A et al (2007) La laparoscopia en el manejo de los tumores ováricos en la infancia. Cir Pediatr 20:15–18

    Google Scholar 

  14. Diamond MP, Baxter JW, Peerman CG et al (1988) Occurrence of ovarian malignancy in childhood and adolescence: a community-wide evaluation. Obstet Gynecol 71:858–860

    CAS  PubMed  Google Scholar 

  15. Van Winter JT, Simmons PS, Podratz KC (1994) Surgically treated adnexal masses in infancy, childhood and adolescence. Am J Obstet Gynecol 170:1780–1789

    PubMed  Google Scholar 

  16. Mann JR, Raafat F, Robinson K et al (1998) UKCCSG’s germ-cell tumour (GCT) studies: Improving outcome for children with malignant extracranial non-gonadal tumours — carboplatin, etoposide, and bleomycin are effective and less toxic than previous regimens. United Kingdom Children’s Cancer Study Group. Med Pediatr Oncol 30:217–227

    Article  CAS  PubMed  Google Scholar 

  17. Cushing B, Giller R, Cullen JW et al (2004) Randomized comparison of combination chemotherapy with etoposide, bleomycin, and either high-dose or standard-dose cisplatin in children and adolescents with high-risk malignant germ cell tumors: a pediatric intergroup study — Pediatric Oncology Group 9049 and Children’s Cancer Group 8882. J Clin Oncol 22:2691–2700

    Article  CAS  PubMed  Google Scholar 

  18. Rogers PC, Olson TA, Cullen JW et al (2004) Treatment of children and adolescents with stage II testicular and stages I and II ovarian malignant germ cell tumors: a pediatric intergroup study — Pediatric oncology group 9048 and Children’s Cancer group 8891. J Clin Oncol 22:3563–3569

    Article  PubMed  Google Scholar 

  19. Marina NM, Cushing B, Giller R et al (1999) Complete surgical excision is effective treatment for children with immature teratomas with or without malignant elements: a Pediatric Oncology Group/Children’s Cancer Group Intergroup Study. J Clin Oncol 17:2137–2143

    CAS  PubMed  Google Scholar 

  20. Wallace WHB, Anderson RA, Irvine DS (2005) Fertility preservation for young patients with cancer: who is at risk and what can be offered? Lancet 6:209–218

    Article  Google Scholar 

  21. Horton Z, Schlatter M, Schultz S (2007) Pediatric germ cell tumors. Surg Oncol 16:205–213

    Article  PubMed  Google Scholar 

  22. Dark GG, Bower M, Newlands ES et al (1997) Surveillance policy for stage I ovarian germ cell tumours. J Clin Oncol 15:620–624

    CAS  PubMed  Google Scholar 

  23. Brassesco MS, Castro-Gamero AM, Valera ET et al (2009) 3q27 aberrations in a childhood ovary teratoma with associated malignant germ cell component. Pediatr Blood Cancer 52:398–401

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to María del Mar Andrés.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Andrés, M.d.M., Costa, E., Cañete, A. et al. Solid ovarian tumours in childhood: a 35-year review in a single institution. Clin Transl Oncol 12, 287–291 (2010). https://doi.org/10.1007/s12094-010-0505-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12094-010-0505-9

Keywords

Navigation