Skip to main content

Advertisement

Log in

Gamma Knife radiosurgery as a primary treatment option for solitary brain metastases from ovarian carcinoma

  • Case Reports
  • Published:
Clinical and Translational Oncology Aims and scope Submit manuscript

Abstract

We present three patients with brain metastasis cases from ovarian carcinoma (BMOC) treated at William Beaumont Hospital with a median follwow-up of 77 months and a mean survival after brain involvement of 23.66 months (range 5–44). Clinical and physical aspects are presented. Between December 2006 and August 2008, three cases of BMOC were treated using Gamma Knife (GK) radiosurgery. All patients had FIGO Stage III primary disease at initial diagnosis. Treatment sequences and features are described. GK achieves excellent local control of BMOC. Other parameters could be considered as biologically effective.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Posner JB (1995) Neurologic complications of cancer. FA Davis, Philadelphia

    Google Scholar 

  2. Knisely JP, Berkey B, Chakravarti A et al (2008) A phase III study of conventional radiation therapy plus thalidomide versus conventional radiation therapy for multiple brain metastases (RTOG 0118). Int J Radiat Oncol Biol Phys 71:79–86

    PubMed  CAS  Google Scholar 

  3. Gaspar L, Scott C, Rotman M et al (1997) Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials. Int J Radiat Oncol Biol Phys 37:745–751

    PubMed  CAS  Google Scholar 

  4. Pectasides D, Pectasides M, Economopoulos T (2006) Brain metastases from epithelian ovarian cancer: a review of literature. Oncologist 11:252–260

    Article  PubMed  Google Scholar 

  5. Patchell RA, Tibbs PA, Walsh JW et al (1990) A randomized trial of surgery in the treatment of single metastases to the brain. N Engl J Med 322: 494–500

    PubMed  CAS  Google Scholar 

  6. Noordijk EM, Vecht CJ, Haaxma-Reiche H et al (1994) The choice of treatment of single brain metastasis should be based on extracranial tumor activity and age. Int J Radiat Oncol Biol Phys 29:711–717

    PubMed  CAS  Google Scholar 

  7. Andrews DW, Scott CB, Sperduto PW et al (2004) Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial. Lancet 363:1665–1672

    Article  PubMed  Google Scholar 

  8. Young DF, Posner JB, Chu F et al (1974) Rapidcourse radiation therapy of cerebral metastasis: results and complications. Cancer 34:1069–1076

    Article  PubMed  CAS  Google Scholar 

  9. Hindo WA, DeTrana FA, Lee MS et al (1970) Large dose increment irradiation in treatment of cerebral metastasis. Cancer 26:138–141

    Article  PubMed  CAS  Google Scholar 

  10. DeAngelis LM, Delattre JY, Posner JB (1989) Radiation-induced dementia in patients cured of brain metastases. Neurology 39:789–796

    PubMed  CAS  Google Scholar 

  11. Asai A, Matsutani M, Kohno T et al (1989) Subacute brain atrophy after radiation therapy for malignant brain tumor. Cancer 63:1962–1974

    Article  PubMed  CAS  Google Scholar 

  12. Cull A, Gregor A, Hopwood P et al (1994) Neurological and cognitive impairment in long-term survivors of small cell lung cancer. Eur J Cancer 30A:1067–1074

    Article  PubMed  CAS  Google Scholar 

  13. Shibamoto Y, Baba F, Oda K et al (2008) Incidence of brain atrophy and decline in Mini-Mental State Examination Score after whole-brain radiotherapy in patients with brain metastasis: a prospective study. Int J Radiat Oncol Biol Phys 72:1168–1173.

    PubMed  Google Scholar 

  14. Aoyama H, Shirato H, Tago M et al (2006) Stereotactic radiosurgery plus whole-brain radiation therapy vs sterotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial. JAMA 295:2483–2491

    Article  PubMed  CAS  Google Scholar 

  15. Welzer G, Fleckenstein K, Schaefer J et al (2008) Memory function before and after whole brain radiotherapy in patients with and without brain metastases. Int J Radiat Oncol Biol Phys 72:1311–1318

    Google Scholar 

  16. Lee YK, Park NH, Kim JW (2008) Gamma-knife radiosurgery as an optimal treatment modality for brain metastases from epithelian ovarian cancer. Gynecol Oncol 108:505–509

    Article  PubMed  Google Scholar 

  17. Monaco E 3rd, Kondziolka D, Mongia S et al (2008) Management of brain metastases from ovarian and endometrial carcinoma with stereotactic radiosurgery. Cancer 113:2610–2614

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Arturo Navarro-Martín.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Navarro-Martín, A., Maitz, A., Manders, M. et al. Gamma Knife radiosurgery as a primary treatment option for solitary brain metastases from ovarian carcinoma. Clin Transl Oncol 11, 326–328 (2009). https://doi.org/10.1007/s12094-009-0362-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12094-009-0362-6

Keywords

Navigation