Abstract
Only 25% of all lung cancers are diagnosed in an early stage allowing surgical treatment. Primary tumours usually concerning lung metastasis are breast, colon, kidney, uterus/cervix, prostate, and head and neck tumours. During recent years many publications have confirmed the effectiveness and reliability of lung radiofrequency ablation (RFA) alone or together with other techniques (chemotherapy, radiotherapy...). Results suggest that survival increase and curative rates of lung radiofrequency are similar to those achieved by more aggressive procedures and present lower rates of complications. Pneumothorax, pleural effusion and alveolar haemorrhage are the most frequent complications. Indications for lung RFA must be individually evaluated by lung cancer committees. Percutaneous lung RFA may be useful in patients with pulmonary primary tumours and metastases, especially in those with nodules smaller than 3 cm and a peripheral location (>1 cm from the hilum). PET/CT seems to be the most accurate technique in patient follow up.
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Jemal A, Thomas A, Murray T et al (2002) Cancer statistics, 2002. CA Cancer J Clin 52:23–47
Smith RA, Glynn TJ (2000) Epidemiology of lung cancer. Radiol Clin North Am 38:453–470
Rami-Porta R, Ball D, Crowley J et al; International Staging Committee; Cancer Research and Biostatistics; Observers to the Committee; Participating Institutions (2007) The IASLC Lung Cancer Staging Project: proposals for the revision of the T descriptors in the forthcoming (seventh) edition of the TNM classification for lung cancer. J Thorac Oncol 2:593–602
Non-small Cell Lung Cancer Collaborative Group (1995) Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trials. BMJ 311:899–909
Higaki F, Okumura Y, Sato S et al (2008) Preliminary retrospective investigation of FDG-PET/CT timing in follow-up of ablated lung tumor. Ann Nucl Med 22:157–163
Simon CJ, Dupuy DE, DiPetrillo TA et al (2007) Pulmonary radiofrequency ablation: long-term safety and efficacy in 153 patients. Radiology 243:268–275
de Baère T, Palussière J, Aupérin A et al (2006) Midterm local efficacy and survival after radiofrequency ablation of lung tumors with minimum follow-up of 1 year: prospective evaluation. Radiology 240:587–596
Lencioni R, Crocetti L, Cioni R et al (2008) Response to radiofrequency ablation of pulmonary tumours: a prospective, intention-to-treat, multicentre clinical trial (the RAPTURE study). Lancet Oncol 9:621–628
Vossen JA, Buijs M, Kamel IR (2006) Assessment of tumor response on MR imaging after locoregional therapy. Tech Vasc Interv Radiol 9:125–132
Hoffmann RT, Jakobs TF, Lubienski A et al (2006) Percutaneous radiofrequency ablation of pulmonary tumors — is there a difference between treatment under general anaesthesia and under conscious sedation? Eur J Radiol 59:168–174
Mulier S, Ni Y, Jamart J et al (2005) Local recurrence after hepatic radiofrequency coagulation: multivariate meta-analysis and review of contributing factors. Ann Surg 242:158–171
Hiraki T, Sakurai J, Tsuda T et al (2006) Risk factors for local progression after percutaneous radiofrequency ablation of lung tumors: evaluation based on a preliminary review of 342 tumors. Cancer 107:2873–2880
Gillams A (2008) Lung tumour ablation — where are we now? Cancer Imaging 8:116–117
Treasure T (2007) Pulmonary metastasectomy: a common practice based on weak evidence. Ann R Coll Surg Engl 89:744–748
Treasure T, Internullo E, Utley M (2008) Resection of pulmonary metastases: a growth industry. Cancer Imaging 8:121–124
Yan TD, King J, Sjarif A et al (2007) Treatment failure after percutaneous radiofrequency ablation for nonsurgical candidates with pulmonary metastases from colorectal carcinoma. Ann Surg Oncol 14:1718–1726
Hiraki T, Mimura H, Gobara H et al (2008) Repeat radiofrequency ablation for local progression of lung tumors: does it have a role in local tumor control? J Vasc Interv Radiol 19:706–711
Qiao X, Tullgren O, Lax I et al (2003) The role of radiotherapy in treatment of stage I non-small cell lung cancer. Lung Cancer 41:1–11
Timmerman RD, Park C, Kavanagh BD (2007) The North American experience with stereotactic body radiation therapy in non-small cell lung cancer. J Thorac Oncol 2[7 Suppl 3]:S101–112
Dupuy DE, DiPetrillo T, Gandhi S et al (2006) Radiofrequency ablation followed by conventional radiotherapy for medically inoperable stage I non-small cell lung cancer. Chest 129:738–745
Jain SK, Dupuy DE, Cardarelli GA et al (2003) Percutaneous radiofrequency ablation of pulmonary malignancies: combined treatment with brachytherapy. AJR Am J Roentgenol 181:711–715
Grieco CA, Simon CJ, Mayo-Smith WW et al (2006) Percutaneous image-guided thermal ablation and radiation therapy: outcomes of combined treatment for 41 patients with inoperable stage I/II non-small-cell lung cancer. J Vasc Interv Radiol 17:1117–1124
Bolliger CT, Perruchoud AP (1998) Functional evaluation of the lung resection candidate. Eur Respir J 11:198–212
Steinke K, Haghighi KS, Wulf S et al (2005) Effect of vessel diameter on the creation of ovine lung radiofrequency lesions in vivo: preliminary results. J Surg Res 124:85–91
Oshima F, Yamakado K, Akeboshi M et al (2004) Lung radiofrequency ablation with and without bronchial occlusion: experimental study in porcine lungs. J Vasc Interv Radiol 15:1451–1456
Hiraki T, Tajiri N, Mimura H et al (2006) Pneumothorax, pleural effusion, and chest tube placement after radiofrequency ablation of lung tumors: incidence and risk factors. Radiology 241: 275–283
Steinke K, Sewell PE, Dupuy D et al (2004) Pulmonary radiofrequency ablation- an international study survey. Anticancer Res 24:339–343
Zhu JC, Yan TD, Morris DL et al (2008) A systematic review of radiofrequency ablation for lung tumors. Ann Surg Oncol 15:1765–1774
White DC, D’Amico TA (2008) Radiofrequency ablation for primary lung cancer and pulmonary metastases. Clin Lung Cancer 9:16–23
Nomura M, Yamakado K, Nomoto Y et al (2008) Complications after lung radiofrequency ablation: risk factors for lung inflammation. Br J Radiol 81: 244–249
Steinke K, King J, Glenn D et al (2003) Radiologic appearance and complications of percutaneous computed tomography-guided radiofrequency-ablated pulmonary metastases from colorectal carcinoma. J Comput Assist Tomogr 27:750–757
Mac Manus MP, Hicks RJ, Matthews JP et al (2003) Positron emission tomography is superior to computed tomography scanning for response assessment after radical radiotherapy or chemoradiotherapy in patients with non-small-cell lung cancer. J Clin Oncol 21:1285–1292
Kang S, Luo R, Liao W et al (2004) Single group study to evaluate the feasibility and complications of radiofrequency ablation and usefulness of post treatment position emission tomography in lung tumours. World J Surg Oncol 2:30
Travaini LL, Trifirò G, Ravasi L et al (2008) Role of [(18)F]FDG-PET/CT after radiofrequency ablation of liver metastases: preliminary results. Eur J Nucl Med Mol Imaging 35:1316–1322
Paudyal B, Oriuchi N, Paudyal P et al (2007) Early diagnosis of recurrent hepatocellular carcinoma with 18F-FDG PET after radiofrequency ablation therapy. Oncol Rep 18:1469–1473
Oyama Y, Nakamura K, Matsuoka T et al (2005) Radiofrequency ablated lesion in the normal porcine lung: long-term follow-up with MRI and pathology. Cardiovasc Intervent Radiol 28:346–353
Hiraki T, Gobara H, Sakurai J et al (2006) Radiofrequency ablation of normal lungs after pulmonary artery embolization with use of degradable starch microspheres: results in a porcine model. J Vasc Interv Radiol 17:1991–1998
Hiraki T, Gobara H, Takemoto M et al (2006) Percutaneous radiofrequency ablation combined with previous bronchial arterial chemoembolization and followed by radiation therapy for pulmonary metastasis from hepatocellular carcinoma. J Vasc Interv Radiol 17:1189–1193
Wasser EJ, Dupuy DE (2008) Microwave ablation in the treatment of primary lung tumors. Semin Respir Crit Care Med 29:384–394
Wolf FJ, Grand DJ et al (2008) Microwave ablation of lung malignancies: effectiveness, CT findings, and safety in 50 patients. Radiology 247: 871–879
Wen J, Duan Y, Zou Y et al (2007) Cryoablation induces necrosis and apoptosis in lung adenocarcinoma in mice. Technol Cancer Res Treat 6: 635–640
Permpongkosol S, Nicol TL, Link RE et al (2007) Differences in ablation size in porcine kidney, liver, and lung after cryoablation using the same ablation protocol. AJR Am J Roentgenol 188:1028–1032
Maiwand MO (1999) The role of cryosurgery in palliation of tracheo-bronchial carcinoma. Eur J Cardiothorac Surg 15:764–768
McTaggart RA, Dupuy DE (2007) Thermal ablation of lung tumors. Tech Vasc Interv Radiol 10: 102–113
Burgess SE, Iwamoto T, Coleman DJ et al (1987) Histologic changes in porcine eyes treated with high-intensity focused ultrasound. Ann Ophthalmol 19:133–138
Wu CC, Chen WS, Ho MC et al (2008) Minimizing abdominal wall damage during high-intensity focused ultrasound ablation by inducing artificial ascites. J Acoust Soc Am 124:674–679
Poff JA, Allen CT, Traughber B et al (2008) Pulsed high-intensity focused ultrasound enhances apoptosis and growth inhibition of squamous cell carcinoma xenografts with proteasome inhibitor bortezomib. Radiology 248:485–491
Salomir R, Delemazure AS, Palussière J et al (2006) Image-based control of the magnetic resonance imaging-guided focused ultrasound thermotherapy. Top Magn Reson Imaging 17:139–151
Salomir R, Palussière J, Fossheim SL et al (2005) Local delivery of magnetic resonance (MR) contrast agent in kidney using thermosensitive liposomes and MR imaging-guided local hyperthermia: a feasibility study in vivo. J Magn Reson Imaging 22):534–540
Pernot M, Aubry JF, Tanter M et al (2007) High power phased array prototype for clinical high intensity focused ultrasound: applications to transcostal and transcranial therapy. Conf Proc IEEE Eng Med Biol Soc 2007:234–237
Vaezy S, Zderic V, Karmy-Jones R et al (2007) Hemostasis and sealing of air leaks in the lung using high-intensity focused ultrasound. J Trauma 62:1390–1395
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Gómez, F.M., Palussière, J., Santos, E. et al. Radiofrequency thermocoagulation of lung tumours. Where we are, where we are headed. Clin Transl Oncol 11, 28–34 (2009). https://doi.org/10.1007/s12094-009-0307-0
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DOI: https://doi.org/10.1007/s12094-009-0307-0