Abstract
Radical orchiectomy is the standard treatment for patients with seminoma. In both bilateral and unilateral testicular cancer, this therapy results in infertility, permanent androgen replacement treatment and significant psychological problems stemming from castration. Given that most patients with germinal cell tumours are long-term survivors, quality of life is becoming more and more relevant in therapeutic decision-making. We present a case of metachronous bilateral seminoma treated with tumour enucleation and adjuvant local radiotherapy. We also provide a review of the literature on the role of radiotherapy in organ sparing.
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References
Huyghe E, Matsuda T, Thonneau P (2003) Increasing incidence of testicular cancer worldwide: a review. J Urol 170:5–11
Coffey J, Birtle AJ, Cogill G et al (2005) A discussion of the biology of testicular cancer and current concepts in the management of stage I and bilateral disease. Clin Oncol 17:441–447
Schmoll HJ, Souchon R, Krege S et al (2004) European consensus on diagnosis and treatment of germ cell cancer: a report of the European Germ Cell Cancer Consensus Group (EGCCCG). Ann Oncol 15:1377–1399
Dieckmann KP, Skakkebaek NE (1999) Carcinoma in situ of the testis: review of biological and clinical features. Int J Cancer 83:815–822
Christensen TB, Daugaard G, Geertsen PF, von der Maase H (1998) Effect of chemotherapy on carcinoma in situ of the testis. Ann Oncol 9:657–660
Heidenreich A, Weibbach L, Holtl W (2001) Organ sparing surgery for malignant germ cell tumor of the testis. J Urol 166:2161–2165
Classen J, Dieckmann K, Bamberg M et al; German Testicular Cancer Study Group (2003) Radiotherapy with 16 Gy may fail to eradicate testicular intraepithelial neoplasia: preliminary communication of a dose-reduction trial of the German Testicular Cancer Study Group. Br J Cancer 88:828–831
Petersen PM, Giwercman A, Daugaard G et al (2002) Effect of graded testicular doses of radiotherapy in patients treated for carcinoma-insitu in the testis. J Clin Oncol 20:1537–1543
Giwercman A, von der Maase H, Berthelsen JG et al (1991) Localized irradiation of testes with carcinoma in situ: effects on Leydig cell function and eradication of malignant germ cells in 20 patients. J Clin Endocrinol Metab 73:596–603
Richie JP (1984) Simultaneous bilateral tumors with unorthodox management. World J Urol 2:74
De Wit R, Fizazi K (2006) Controversies in the management of clinical stage I testis cancer. J Clin Oncol 24:5482–5492
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Flaquer, A., Álvarez, A. & Sánchez, S.M. Role of radiotherapy in organ-sparing treatment of seminoma. Clin Transl Oncol 10, 679–681 (2008). https://doi.org/10.1007/s12094-008-0272-z
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DOI: https://doi.org/10.1007/s12094-008-0272-z