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Clinical and Translational Oncology

, Volume 10, Issue 9, pp 538–542 | Cite as

Role of CHK2 in cancer development

  • Rosario PeronaEmail author
  • Verónica Moncho-Amor
  • Rosario Machado-Pinilla
  • Cristóbal Belda-Iniesta
  • Isabel Sánchez Pérez
Educational Series Green Series

Abstract

DNA repair pathways enable tumour cells to survive DNA damage induced by external agents such as therapeutic treatments. Signalling cascades involved in these pathways comprise the DNA-dependent protein kinase (DNA-PK), Ataxia-telangiectasia mutated (ATM), ATM and Rad3 related (ATR) and checkpoint kinases I and 2 (Chk1/Chk2), among others. ATM and ATR phosphorylate, respectively, Chk2 and Chk1, leading to activation of checkpoints. Chk2 acts as a signal distributor, dispersing checkpoint signal to downstream targets such as p53, Cdc25A, Cdc25C, BRCA1 and E2F1. A role of Chk2 as a candidate tumour suppressor has been suggested based on both mouse genetics and somatic tumour studies. We will discuss here the possible role of this kinase in human carcinogenesis and the possibility to use it as a target to increment DNA damage in cancer cells in response to DNAdamaging therapies.

Keywords

CHK2 ATM ATR DNA damage Checkpoints Chemotherapy 

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Copyright information

© Feseo 2008

Authors and Affiliations

  • Rosario Perona
    • 1
    • 2
    Email author
  • Verónica Moncho-Amor
    • 1
    • 2
  • Rosario Machado-Pinilla
    • 1
    • 2
  • Cristóbal Belda-Iniesta
    • 3
  • Isabel Sánchez Pérez
    • 1
    • 2
  1. 1.Instituto de Investigaciones Biomédicas C.S.I.C./U.A.M.MadridSpain
  2. 2.Translational Oncology Unit C.S.I.C./U.A.M.CIBER de Enfermedades Raras (CIBERER)ValenciaSpain
  3. 3.Translational Oncology Unit CSIC/UAM at Medical Oncology DivisionUniversity Hospital La Paz Universidad Autónoma de MadridMadridSpain

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