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Molecular biology of pancreatic cancer

  • Cristóbal Belda-Iniesta
  • Inmaculada Ibáñez de Cáceres
  • Jorge Barriuso
  • Javier de Castro Carpeño
  • Manuel González Barón
  • Jaime FeliúEmail author
Educational Series Blue Series

Abstract

Pancreatic cancer is a leading cause of cancer death. This devastating disease has the horrible honour of close to equal incidence and mortality rates. Late diagnosis and a constitutive resistance to every chemotherapy approach are responsible for this scenario. However, molecular biology tools in cooperation with translational efforts have dissected several secrets that underlie pancreatic cancer. Progressive acquisition of malignant, invasive phenotypes from pre-malignant lesions, recent revelations on core signalling pathways and new targeted designed trials offer a better future for pancreatic cancer patients. This review will summarise recent advances in the molecular biology of pancreatic cancer.

Keywords

Pancreatic cancer K-ras Cyclins TGFβ STAT3 EGFr 

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Copyright information

© Feseo 2008

Authors and Affiliations

  • Cristóbal Belda-Iniesta
    • 1
    • 2
  • Inmaculada Ibáñez de Cáceres
    • 3
  • Jorge Barriuso
    • 1
  • Javier de Castro Carpeño
    • 1
  • Manuel González Barón
    • 1
    • 2
  • Jaime Feliú
    • 1
    Email author
  1. 1.Translational Oncology Unit CSIC/UAM at Medical Oncology DivisionUniversity Hospital La Paz Universidad Autónoma de MadridMadridSpain
  2. 2.MD Anderson International Cancer Center EspañaMadridSpain
  3. 3.Translational Oncology Unit (CSIC/UAM) at Biomedical Research Institute “Alberto Sols”Consejo Superior de Investigaciones CientíficasMadridSpain

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