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Bronchoesophageal fistula in a patient with non-Hodgkin’s lymphoma


Bronchoesophageal fistula secondary to lymphoma is a very rare condition, usually associated with chemo-radiotherapy. We report a case of a patient with a non-Hodgkin’s lymphoma (NHL) who, after chemotherapy, developed an oesophago-tracheal fistula. Initially it was treated conservatively but due to the lack of response, a stent was inserted. After nearly one year without success, surgery was considered. Right thoracotomy oesophagectomy and closure of the tracheal defect with an intercostal muscle flap and pericardial patch was performed. This was followed by laparoscopic creation of a gastric tube, which was successfully anastomosed to the cervical oesophagus through a cervicotomy. Unlike oesophageal cancer, NHL can have a good prognosis, so curative treatment of the fistula can be considered. Conservative treatment must always be the first option, leaving stenting or surgery for when the problem persists.

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  1. 1.

    Wesselhoerft CW, Keshishian JM (1968) Acquired non-malignant esophagotracheal and esophagobronchial fistulas. Ann Thorac Surg 6:187–195

    Article  Google Scholar 

  2. 2.

    Uenogawa K, Hatta Y, Oshiro S et al (2005) Bronchoesophageal fistula in a patient with untreated malignant lymphoma. Rinsho Ketsueki 46:1071–1073

    PubMed  Google Scholar 

  3. 3.

    Morrisen FS, Critz G, Tatum WT, Strauss HK (1973) Hodgkin’s disease of the esophagus: successful treatment of a rare complication. Cancer 31:1244–1246

    Article  Google Scholar 

  4. 4.

    West WO, Bouroncle BA (1960) Spontaneous perforation of the esophagus in Hodgkin’s disease. Am J Gastroenterol 33:335

    PubMed  CAS  Google Scholar 

  5. 5.

    Tomaselli F, Maier A, Sankin O et al (2001) Successful endoscopical sealing of malignant esophageotracheal fistulae by using a covered self-expandable stenting system. Eur J Cardiothorac Surg 20:734–738

    PubMed  Article  CAS  Google Scholar 

  6. 6.

    Fernando HC, Benfield JR (1996) Surgical management and treatment of esophageal fistula. Surg Clin North Am 76:1123–1135

    PubMed  Article  CAS  Google Scholar 

  7. 7.

    Zueger O, Bolliger CT, Quadri F et al (1997) Conservative management of a bronchooesophageal fistula in a patient with non-Hodgkin’s lymphoma. Respiration 64:388–391

    PubMed  CAS  Article  Google Scholar 

  8. 8.

    Hulscher JB, ter Hofstede E, Kloek J et al (2000) Injury to the major airways during subtotal esophagectomy: incidence, management and sequelae. J Thorac Cardiovasc Surg 120:1093–1096

    PubMed  Article  CAS  Google Scholar 

  9. 9.

    Marty-Ane CH, Prudhome M, Fabre JM et al (1995) Tracheoesophagogastric anastomosis fistula: a rare complication of esophagectomy. Ann Thorac Surg 43:672–677

    Google Scholar 

  10. 10.

    Millikan KW, Pytynia KB (1997) Repair of tracheal defect with Goretex graft during resection of carcinoma of the esophagus. J Surg Oncol 66:134–137

    PubMed  Article  CAS  Google Scholar 

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Correspondence to Víctor Valenti.

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Valenti, V., Martínez-Cecilia, D., Priego, P. et al. Bronchoesophageal fistula in a patient with non-Hodgkin’s lymphoma. Clin Transl Oncol 10, 377–379 (2008).

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  • Bronchoesophageal fistula
  • Non-Hodgkin’s lymphoma
  • Oesophagectomy