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Radiation therapy for the treatment of benign vascular, skeletal and soft tissue diseases

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Abstract

The concept of radiation therapy for the treatment of benign diseases refers to the use of moderate to high-energy ionising radiation as part of the treatment of non-malignant, but not necessarily harmless, diseases. The usefulness of radiation therapy, based on the anti-inflammatory properties of ionising radiation, has long been known. Apart from the treatment of intracranial benign tumours, such as meningiomas and neurinomas, the prevention of cardiovascular restenosis or treatment of skeletal degenerative diseases are, without doubt, the main fields of action for radiation therapy in benign conditions. Nonetheless, many other non-cancer entities may benefit from ionising radiation therapy treatment. The purpose of this review is to highlight and update indications for treatment with radiation therapy in benign conditions, focusing on skeletal degenerative processes, vascular conditions and soft tissue diseases.

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References

  1. Micke O, Seegenschmiedt MH; German Working Group on Radiotherapy in Germany (2002) Consensus guidelines for radiation therapy of benign diseases: a multicenter approach in Germany. Int J Radiat Oncol Biol Phys 52:496–513

    PubMed  Google Scholar 

  2. Trott KR, Kamprad F (1999) Radiobiological mechanisms of anti-inflammatory radiotherapy. Radiother Oncol 51:197–203

    Article  PubMed  CAS  Google Scholar 

  3. Hildebrandt G, Radlingmayr A, Rosenthal S et al (2003) Low-dose radiotherapy (LD-RT) and the modulation of iNOS expression in adjuvant-induced arthritis in rats. Int J Radiat Biol 79:993–1001

    Article  PubMed  CAS  Google Scholar 

  4. Hildebrandt G, Loppnow G, Jahns J et al (2003) Inhibition of the iNOS pathway in inflammatory macrophages by low-dose X-irradiation in vitro. Is there a time dependence? Strahlenther Onkol 179:158–166

    Article  PubMed  Google Scholar 

  5. Broerse JJ, Bartstra RW, van Bekkum DW et al (2000) The carcinogenic risk of high dose total body irradiation in non-human primates. Radiother Oncol. 54(3):247–253.

    Article  PubMed  CAS  Google Scholar 

  6. Broerse JJ, Snijders-Keilholz A, Jansen JT et al (1999) Assessment of a carcinogenic risk for treatment of Graves’ ophthalmopathy in dependence on age and irradiation geometry. Radiother Oncol 53:205–208

    Article  PubMed  CAS  Google Scholar 

  7. Broerse JJ, Van Bekkum DW (1991) Animal models of radiation carcinogenesis and developments in molecular biology. Radiat Environ Biophys 30:161–163

    Article  PubMed  CAS  Google Scholar 

  8. Broerse JJ, Jansen JTM, Seegenschmiedt MH (2004) Carcinogenic risks in radiotherapy of benign diseases from head to heel. Radiother Oncol 71[Suppl 1]:1

    Google Scholar 

  9. Jansen JT, Broerse JJ, Zoetelief J et al (2005) Estimation of the carcinogenic risk of radiotherapy of benign diseases from shoulder to heel. Radiother Oncol 76:270–277

    Article  PubMed  Google Scholar 

  10. Nag S, Cole PE, Crocker I et al (1999) The American Brachytherapy Society perspective on intravascular radiotherapy. Cardiovasc Radiat Med 1:8–19

    Article  PubMed  CAS  Google Scholar 

  11. Pokrajac B, Potter R, Wolfram RM et al (2005) Endovascular brachytherapy prevents restenosis after femoropopliteal angioplasty: results of the Vienna-3 randomised multicenter study. Radiother Oncol 74:3–9

    Article  PubMed  Google Scholar 

  12. Leon MB, Teirstein PS, Moses JW et al (2001) Localized intracoronary gamma-radiation therapy to inhibit the recurrence of restenosis after stenting. N Engl J Med 344:250–256

    Article  PubMed  CAS  Google Scholar 

  13. Pokrajac B, Schmid R, Kirisits C et al (2002) Possible impact of iridium-192 source centering on restenosis rate after femoro-popliteal angioplasty and endovascular brachytherapy in Vienna-2 study. Radiother Oncol 63:97–102

    Article  PubMed  Google Scholar 

  14. Pokrajac B, Potter R, Maca T et al (2000) Intraarterial (192)Ir high-dose-rate brachytherapy for prophylaxis of restenosis after femoropopliteal percutaneous transluminal angioplasty: the prospective randomized Vienna-2-trial radiotherapy parameters and risk factors analysis. Int J Radiat Oncol Biol Phys 48:923–931

    Article  PubMed  CAS  Google Scholar 

  15. Hall EJ, Miller RC, Brenner DJ (1999) Radiobiological principles in intravascular irradiation. Cardiovasc Radiat Med 1:42–47

    Article  PubMed  CAS  Google Scholar 

  16. Nath R, Amol H, Coffey C et al (1999) Intravascular brachytherapy physics: report of the AAPM Radiation Therapy Committee Task Group No. 60. Med Phys 26:119–152

    Article  PubMed  CAS  Google Scholar 

  17. Raizner AE, Oesterle SN, Waksman R et al (2000) Inhibition of restenosis with beta-emitting radiotherapy: Report of the Proliferation Reduction with Vascular Energy Trial (PREVENT). Circulation 102:951–958

    PubMed  CAS  Google Scholar 

  18. Waksman R, Ajani AE, White RL et al (2004) Five-year follow-up after intracoronary gamma radiation therapy for in-stent restenosis. Circulation 109:340–344

    Article  PubMed  Google Scholar 

  19. Hofmann WJ, Kopp M, Sedlmayer F et al (2003) External beam radiation for prevention of intimal hyperplasia in peripheral arterial bypasses. Int J Radiat Oncol Biol Phys 56:1180–1183

    Article  PubMed  Google Scholar 

  20. Zabakis P, Kardamakis DM, Siablis D et al (2005) External beam radiation therapy reduces the rate of re-stenosis in patients treated with femoral stenting: results of a randomised study. Radiother Oncol 74:11–16

    Article  PubMed  Google Scholar 

  21. van Tongeren RB, Levendag PC, Coen VL et al (2003) External beam radiation therapy to prevent anastomotic intimal hyperplasia in prosthetic arteriovenous fistulas: results of a randomized trial. Radiother Oncol 69:73–77

    Article  PubMed  Google Scholar 

  22. Parikh S, Nori D, Rogers D et al (1999) External beam radiation therapy to prevent postangioplasty dialysis access restenosis: a feasibility study. Cardiovasc Radiat Med 1:36–41

    Article  PubMed  CAS  Google Scholar 

  23. Rosendahl S, Christoffersen JK, Norgaard M (1977) Para-articular ossification following hip replacement. 70 arthroplasties ad modum Moore using McFarland’s approach. Acta Orthop Scand 48:400–404

    PubMed  CAS  Google Scholar 

  24. Seegenschmiedt MH, Martus P, Goldmann AR et al (1994) Preoperative versus postoperative radiotherapy for prevention of heterotopic ossification (HO): first results of a randomized trial in high-risk patients. Int J Radiat Oncol Biol Phys 30:63–73

    PubMed  CAS  Google Scholar 

  25. Craven PL, Urist MR (1971) Osteogenesis by radioisotope labelled cell populations in implants of bone matrix under the influence of ionizing radiation. Clin Orthop Relat Res 76:231–233

    Article  PubMed  CAS  Google Scholar 

  26. Heyd R, Strassmann G, Schopohl B, Zamboglou N (2001) Radiation therapy for the prevention of heterotopic ossification at the elbow. J Bone Joint Surg Br 83:332–334

    Article  PubMed  CAS  Google Scholar 

  27. Brooker AF, Bowerman JW, Robinson RA, Riley LH Jr (1973) Ectopic ossification following total hip replacement. Incidence and a method of classification. J Bone Joint Surg Am 55:1629–1632

    PubMed  CAS  Google Scholar 

  28. Moed BR, Karges DE (1994) Prophylactic indomethacin for the prevention of heterotopic ossification after acetabular fracture surgery in high-risk patients. J Orthop Trauma 8:34–39

    Article  PubMed  CAS  Google Scholar 

  29. Cella JP, Salvati EA, Sculco TP (1988) Indomethacin for the prevention of heterotopic ossification following total hip arthroplasty. Effectiveness, contraindications, and adverse effects. J Arthroplasty 3:229–234

    Article  PubMed  CAS  Google Scholar 

  30. Pakos EE, Ioannidis JP (2004) Radiotherapy vs. nonsteroidal anti-inflammatory drugs for the prevention of heterotopic ossification after major hip procedures: a meta-analysis of randomized trials. Int J Radiat Oncol Biol Phys 60:888–895

    PubMed  CAS  Google Scholar 

  31. Childs HA 3rd, Cole T, Falkenberg E et al (2000) A prospective evaluation of the timing of postoperative radiotherapy for preventing heterotopic ossification following traumatic acetabular fractures. Int J Radiat Oncol Biol Phys 47:1347–1352

    PubMed  Google Scholar 

  32. Gregoritch SJ, Chadha M, Pelligrini VD et al (1994) Randomized trial comparing preoperative versus postoperative irradiation for prevention of heterotopic ossification following prosthetic total hip replacement: preliminary results. Int J Radiat Oncol Biol Phys 30:55–62

    PubMed  CAS  Google Scholar 

  33. Pellegrini VD Jr, Evarts CM (1992) Radiation prophylaxis of heterotopic bone formation following total hip arthroplasty: current status. Semin Arthroplasty 3:156–166

    PubMed  Google Scholar 

  34. Pellegrini VD Jr, Gregoritch SJ (1996) Preoperative irradiation for prevention of heterotopic ossification following total hip arthroplasty. J Bone Joint Surg Am 78:870–881

    PubMed  Google Scholar 

  35. Seegenschmiedt MH, Makoski HB, Micke O; German Cooperative Group on Radiotherapy for Benign Diseases (2001) Radiation prophylaxis for heterotopic ossification about the hip joint — a multicenter study. Int J Radiat Oncol Biol Phys 51:756–765

    PubMed  CAS  Google Scholar 

  36. van Leeuwen WM, Deckers P, de Lange WJ (1998) Preoperative irradiation for prophylaxis of ectopic ossification after hip arthroplasty. A randomized study in 62 hips. Acta Orthop Scand 69:116–118

    Article  PubMed  Google Scholar 

  37. Koelbl O, Seufert J, Pohl F, Tauscher A et al (2003) Preoperative irradiation for prevention of heterotopic ossification following prosthetic total hip replacement results of a prospective study in 462 hips. Strahlenther Onkol 179:767–773

    Article  PubMed  Google Scholar 

  38. Slawson RG, Poka A, Bathon H et al (1989) The role of post-operative radiation in the prevention of heterotopic ossification in patients with post-traumatic acetabular fracture. Int J Radiat Oncol Biol Phys 17:669–672

    PubMed  CAS  Google Scholar 

  39. Haas ML, Kennedy AS, Copeland CC et al (1999) Utility of radiation in the prevention of heterotopic ossification following repair of traumatic acetabular fracture. Int J Radiat Oncol Biol Phys 45:461–466

    PubMed  CAS  Google Scholar 

  40. Meyer J, Hixson W, Jennelle R et al (1996) Prophylactic post-operative radiotherapy prevents heterotopic ossification following traumatic acetabular fracture. Int J Radiat Oncol Biol Phys 36:360

    Article  Google Scholar 

  41. Anglen JO, Moore KD (1996) Prevention of heterotopic bone formation after acetabular fracture fixation by single-dose radiation therapy: a preliminary report. J Orthop Trauma 10:258–263

    Article  PubMed  CAS  Google Scholar 

  42. Glatzel M, Frohlich D, Kraub A, Basecke S (2002) Results of radiotherapy for gonarthrosis. Benign News 3:9–11

    Google Scholar 

  43. Seegenschmiedt MH, Keilholz L (1998) Epicondylopathia humeri (EPH) and peritendinitis humeroscapularis (PHS): evaluation of radiation therapy long-term results and literature review. Radiother Oncol 47:17–28

    Article  PubMed  CAS  Google Scholar 

  44. Boike AM, Snyder AJ, Roberto PD, Tabbert WG (1993) Heel spur surgery. A transverse plantar approach. J Am Podiatr Med Assoc 83:39–42

    PubMed  CAS  Google Scholar 

  45. Glatzel M, Basecke S, Kraub A, Frohlich D (2002) Radiotherapy for plantar heel spur. Benign News 3:18–19

    Google Scholar 

  46. Schneider O, Stuckle CA, Gott C et al (2002) Effectiveness and prognostic factors of radiotherapy of painful plantar heel spurs. Benign News 3:3–5

    Google Scholar 

  47. Mucke R, Schonekaes K, Micke O et al (2003) Low-dose radiotherapy for painful heel spur. Retrospective study of 117 patients. Strahlenther Onkol 179:774–778

    Article  PubMed  Google Scholar 

  48. Seegenschmiedt MH, Keilholz L, Katalinic A et al (1996) Heel spur: radiation therapy for refractory pain — results with three treatment concepts. Radiology 200:271–276

    PubMed  CAS  Google Scholar 

  49. Kahn MA (1989) Ameloblastoma in young persons: a clinicopathologic analysis and etiologic investigation. Oral Surg Oral Med Oral Pathol 67:706–715

    Article  PubMed  CAS  Google Scholar 

  50. Ord RA, Blanhaert RH, Nikitakis NG, Sauk JJ (2002) Ameloblastoma in children. J Oral Maxillofac Surg 60:762–770

    Article  PubMed  CAS  Google Scholar 

  51. Li TJ, Wu YT, Yu SF, Yu GY (2000) Unicystic ameloblastoma: a clinicopathologic study of 33 Chinese patients. Am J Surg Pathol 24:1385–1392

    Article  PubMed  CAS  Google Scholar 

  52. Kim SG, Jang HS (2001) Ameloblastoma: a clinical, radiographic, and histopathologic analysis of 71 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91:649–653

    Article  PubMed  CAS  Google Scholar 

  53. Atkinson CH, Harwood AR, Cummings BJ (1984) Ameloblastoma of the jaw. A reappraisal of the role of megavoltage irradiation. Cancer 53:869–873

    Article  PubMed  CAS  Google Scholar 

  54. Vergel de Dios AM, Bond JR, Shives TC, McLeod RA (1992) Aneurysmal bone cyst: a clinicopathologic study of 238 cases. Cancer 69:2921–2931

    Article  PubMed  CAS  Google Scholar 

  55. Papagelopoulos PJ, Currier BL, Shaughnessy WJ et al (1998) Aneurysmal bone cyst of the spine. Management and outcome. Spine 23:621–628

    Article  PubMed  CAS  Google Scholar 

  56. Marks RD, Scruggs HJ, Wallace KM, Fenn JO (1976) Megavoltage therapy in patients with aneurysmal bone cysts. Radiology 118:421–424

    PubMed  Google Scholar 

  57. Freigenberg SJ, Marcus RB, Zlotecki RA et al (2001) Megavoltage radiotherapy for aneurysmal bone cysts. Int J Radiat Oncol Biol Phys 49:1243–1247

    Google Scholar 

  58. Montero A, Morera R, Hervás A et al (2004) Role of radiation therapy in the management of recurrent aneurysmal bone cysts. Radiother Oncol 71[Suppl 1]:26

    Google Scholar 

  59. Rodrigues CI, Njo KH, Karim AB (1995) Results of radiotherapy and vitamin E in the treatment of Peyronie’s disease. Int J Radiat Oncol Biol Phys 31:571–576

    PubMed  CAS  Google Scholar 

  60. Incrocci L, Wijnmaalen A, Slob AK et al (2000) Low-dose radiotherapy in 179 patients with Peyronie’s disease: treatment outcome and current sexual functioning. Int J Radiat Oncol Biol Phys 47:1353–1356

    PubMed  CAS  Google Scholar 

  61. Incrocci L, Hop WC, Slob AK (2000) Current sexual functioning in 106 patients with Peyronie’s disease treated with radiotherapy 9 years earlier. Urology 56:1030–1034

    Article  PubMed  CAS  Google Scholar 

  62. Baird KS, Crossan JF, Ralston SH (1993) Abnormal growth factor and cytokine expression in Dupuytren’s contracture. J Clin Pathol 46:425–428

    Article  PubMed  CAS  Google Scholar 

  63. Igarashi A, Nashiro K, Kikuchi K et al (1996) Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders. J Invest Dermatol 106:729–733

    Article  PubMed  CAS  Google Scholar 

  64. Rubin P, Soni A, Williams JP (1999) The molecular and cellular biologic basis for the radiation treatment of benign proliferative diseases. Semin Radiat Oncol 9:203–214

    Article  PubMed  CAS  Google Scholar 

  65. Kohler AH (1984) Radiotherapy of Dupuytren’s contracture. Radiobiol Radiother (Berl) 25:851–853

    CAS  Google Scholar 

  66. Keilholz L, Seegenschmiedt MH, Sauer R (1996) Radiotherapy for prevention of disease progression in early-stage Dupuytren’s contracture: initial and long-term results. Int J Radiat Oncol Biol Phys 36:891–897

    PubMed  CAS  Google Scholar 

  67. Seegenschmiedt MH, Olschewski T, Guntrum F (2001) Optimization of radiotherapy in Dupuytren’s disease. Initial results of a controlled trial. Strahlenther Onkol 177:74–81

    Article  PubMed  CAS  Google Scholar 

  68. Seegenschmiedt MH, Attassi M (2003) Radiation therapy for Morbus Ledderhose — indication and clinical results. Strahlenther Onkol 179:847–853

    Article  PubMed  Google Scholar 

  69. Stout AP (1948) Fibrosarcoma. Cancer 1:30–63

    Article  CAS  PubMed  Google Scholar 

  70. Acker JC, Bossen EH, Halperin EC (1993) The management of desmoid tumors. Int J Radiat Oncol Biol Phys 26:851–858

    PubMed  CAS  Google Scholar 

  71. McKinnon JG, Neifeld JP, Kay S et al (1989) Management of desmoid tumors. Surg Gynecol Obstet 169:104–106

    PubMed  CAS  Google Scholar 

  72. Reitamo JJ, Scheinin TM, Hayry P (1986) The desmoid syndrome. New aspects in the cause, pathogenesis and treatment of the desmoid tumor. Am J Surg 151:230–237

    Article  PubMed  CAS  Google Scholar 

  73. Klein WA, Miller HH, Anderson M, DeCosse JJ (1987) The use of indomethacin, sulindac, and tamoxifen for the treatment of desmoid tumors associated with familial polyposis. Cancer 60:2863–2868

    Article  PubMed  CAS  Google Scholar 

  74. Posner MC, Shiu MH, Newsome JL et al (1989) The desmoid tumor. Not a benign disease. Arch Surg 124:191–196

    PubMed  CAS  Google Scholar 

  75. Kirschner MJ, Sauer R (1993) The role of radiotherapy in the treatment of desmoid tumors. Strahlenther Onkol 169:77–82

    PubMed  CAS  Google Scholar 

  76. Micke O, Seegenschmiedt MH, German Cooperative Group on Radiotherapy for Benign Diseases (2005) Radiation therapy for aggressive fibromatosis (desmoid tumors): results of a national Patterns of Care Study. Int J Radiat Oncol Biol Phys 61:882–891

    PubMed  Google Scholar 

  77. Leibel SA, Wara WM, Hill DR et al (1983) Desmoid tumors: local control and patterns of relapse following radiation therapy. Int J Radiat Oncol Biol Phys 9:1167–1171

    PubMed  CAS  Google Scholar 

  78. Nuyttens JJ, Rust PF, Thomas CR et al (2000) Surgery versus radiation therapy for patients with aggressive fibromatosis or desmoid tumors: a comparative review of 22 articles. Cancer 88:1517–1523

    Article  PubMed  CAS  Google Scholar 

  79. Jelinek JA, Stelzer KJ, Conrad E et al (2001) The efficacy of radiotherapy as postoperative treatment for desmoid tumors. Int J Radiat Oncol Biol Phys 50:121–125

    PubMed  CAS  Google Scholar 

  80. Keus R, Bartelink H (1986) The role of radiotherapy in the treatment of desmoid tumours. Radiother Oncol 7:1–5

    Article  PubMed  CAS  Google Scholar 

  81. Karakousis CP, Mayordomo J, Zografos GC, Driscoll DL (1993) Desmoid tumors of the trunk and extremity. Cancer 72:1637–1641

    Article  PubMed  CAS  Google Scholar 

  82. Mathur R, Braunstein GD (1997) Gynecomastia: pathomechanisms and treatment strategies. Horm Res 48:95–102

    Article  PubMed  CAS  Google Scholar 

  83. Tyrrell CJ, Payne H, Tammela TL et al (2004) Prophylactic breast irradiation with a single dose of electron beam radiotherapy (10 Gy) significantly reduces the incidence of bicalutamide-induced gynecomastia. Int J Radiat Oncol Biol Phys 60:476–483

    PubMed  Google Scholar 

  84. Iversen P, Tyrrell CJ, Kaisary AV et al (2000) Bicalutamide monotherapy compared with castration in patients with nonmetastatic locally advanced prostate cancer: 6.3 years of followup. J Urol 164:1579–1582

    Article  PubMed  CAS  Google Scholar 

  85. Fass D, Steinfeld A, Brown J, Tessler A (1986) Radiotherapeutic prophylaxis of estrogen-induced gynecomastia: a study of late sequela. Int J Radiat Oncol Biol Phys 12:407–408

    PubMed  CAS  Google Scholar 

  86. Widmark A, Fossa SD, Lundmo P et al (2003) Does prophylactic breast irradiation prevent antiandrogen-induced gynecomastia? Evaluation of 253 patients in the randomized Scandinavian trial SPCG-7/SFUO-3. Urology 61:145–151

    Article  PubMed  CAS  Google Scholar 

  87. Van Poppel H, Tyrrell CJ, Haustermans K et al (2005) Efficacy and tolerability of radiotherapy as treatment for bicalutamide-induced gynaecomastia and breast pain in prostate cancer. Eur Urol 47:587–592

    Article  PubMed  Google Scholar 

  88. Pastushyn AI, Slin’ko EI, Mirzoyeva GM (1998) Vertebral hemangiomas: diagnosis, management, natural history and clinicopathological correlates in 86 patients. Surg Neurol 50:535–547

    Article  PubMed  CAS  Google Scholar 

  89. Bailey P, Bucy PC (1929) Cavernous hemangioma of the vertebral column. J Am Med Assoc 92:1748–1751

    Google Scholar 

  90. Heyd R, Strassmann G, Filipowicz I et al (2001) Radiotherapy in vertebral hemangioma. Rontgenpraxis 53:208–220

    PubMed  CAS  Google Scholar 

  91. Rades D, Bajrovic A, Alberti W, Rudat V (2003) Is there a dose-effect relationship for the treatment of symptomatic vertebral hemangioma? Int J Radiat Oncol Biol Phys 55:178–181

    Article  PubMed  Google Scholar 

  92. Kasabach HH, Merritt KK (1940) Capillary hemangioma with extensive purpura: a report of a case. Am J Dis Child 59:1063–1070

    Google Scholar 

  93. Hesselmann S, Micke O, Marquardt T et al (2002) Case report: Kasabach-Merritt syndrome: a review of the therapeutic options and a case report of successful treatment with radiotherapy and interferon alpha. Br J Radiol 75:180–184

    PubMed  CAS  Google Scholar 

  94. El-Dessouky M, Azmy AF, Raine PA, Young DG (1988) Kasabach-Merritt syndrome. J Pediatr Surg 23:109–111

    Article  PubMed  CAS  Google Scholar 

  95. Guix B (2004) Radiotherapy concepts for keloids: current options and clinical results. Radiother Oncol 71:s15

    Google Scholar 

  96. Malaker K, Vijayraghavan K, Hodson I, Al Yafi T (2004) Retrospective analysis of treatment of unresectable keloids with primary radiation over 25 years. Clin Oncol (R Coll Radiol) 16:290–298

    CAS  Google Scholar 

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  1. Department of Radiation Oncology, Hospital Ramón y Cajal, Ctra. Colmenar Viejo. km. 9,100, ES-28034, Madrid, Spain

    Ángel Montero Luis, Raúl Hernanz de Lucas, Asunción Hervás Morón, Eva Fernández Lizarbe, Sonsoles Sancho García, Carmen Vallejo Ocaña, Alfredo Polo Rubio & Alfredo Ramos Aguerri

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  1. Ángel Montero Luis
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  2. Raúl Hernanz de Lucas
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Correspondence to Ángel Montero Luis.

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Montero Luis, Á., Hernanz de Lucas, R., Hervás Morón, A. et al. Radiation therapy for the treatment of benign vascular, skeletal and soft tissue diseases. Clin Transl Oncol 10, 334–346 (2008). https://doi.org/10.1007/s12094-008-0209-6

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