Abstract
This is a rare case of a patient with type 1 multiple endocrine neoplasia (MEN-1) syndrome. The case is further unusual in that the glucagonoma debuted with two synchronic pancreatic masses at the time of diagnosis and with pulmonary metastases as the primary site of metastasis and not the more usual site of the liver.
Similar content being viewed by others
References
Alexander HR, Jensen R (2005) Cancer of the endocrine system: pancreatic endocrine tumors. In: De Vita J, De Vita V, Hellman S, Rosenberg S (eds) Principles & practice of oncology. Lippincot-Raven Publishers, Philadelphia, pp 1694–1695
Öberg K, Eriksson B (2005) Endocrine tumors of the pancreas. Best Pract Res Clin Gastroenterol 19:753–781
Ramage JK, Davies AHG, Ardill J et al (2005) Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours. Gut 54[Suppl IV]:iv1–iv16
Grama D, Skogseid B, Wilander E et al (1992) Pancreatic tumors in multiple endocrine neoplasia type 1: clinical presentation and surgical treatment. World J Surg 16:611–618
Levy-Bohbot N, Merle C, Goudet P et al (2004) Prevalence, characteristics and prognosis of MEN 1-associated glucagonomas, VIPomas, and somatostatinomas: Study from the GTE (Groupe des Tumeurs Endocrines) registry. Gastroenterol Clin Biol 28:1075–1081
Kaltsas GA, Besser GM, Grossman AB (2004) The diagnosis and medical management of advanced neuroendocrine tumors. Endocr Rev 25:458–511
Jensen RT (2000) Carcinoid and pancreatic endocrine tumors: recent advances in molecular pathogenesis, localization, and treatment. Curr Opin Oncol 12:368–377
Chun J, Doherty GM (2001) Pancreatic endocrine tumors. Curr Opin Oncol 13:52–56
Chastain MA (2001) The glucagonoma syndrome: a review of its features and discussion of new perspectives. Am J Med Sci 321:306–320
Azimmuddin K, Chamberlain RS (2001) The surgical management of pancreatic neuroendocrine tumors. Surg Clin North Am 81:511–525
Sarmiento JM, Que FG, Grant CS et al (2002) Concurrent resections of pancreatic islet cell cancers with synchronous hepatic metastases: outcomes of an aggressive approach. Surgery 132:976–982
Hellman P, Andersson M, Rastad J et al (2000) Surgical strategy for large or malignant endocrine pancreatic tumors. World J Surg 24:1353–1360
Tomassetti P, Migliori M, Corinaldesi R, Gullo L (2000) Treatment of gastroenteropancreatic neuroendocrine tumours with octreotide LAR. Aliment Pharmacol Ther 14:557–560
Eriksson B, Renstrup J, Imam H et al (1997) High-dose treatment with lanreotide of patients with advanced neuroendocrine gastrointestinal tumors. Clinical and biological effects. Ann Oncol 8:1041–1044
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Gutiérrez, V., Cobo, M., Olea, D. et al. Glucagonoma with two pancreatic masses and pulmonary metastases as debut of MEN-1. Clin Transl Oncol 9, 674–677 (2007). https://doi.org/10.1007/s12094-007-0121-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12094-007-0121-5