Bone fracture is a well known possible late complication of radiation treatment. Little has been written about fractures of long bones after irradiation. We present a case of femur bone necrosis secondary to postoperative radiation for a soft tissue sarcoma of the thigh 20 years earlier. Fixation of the diaphyseal fracture and radiological evolution are described.
Radiation therapy Late effects Surgery Soft tissue sarcoma Pathological fracture Osteoradionecrosis
This is a preview of subscription content, log in to check access.
Rosenberg SA, Tepper J, Glatstein E et al (1982) The treatment of soft tissue sarcomas of the extremities. Prospective randomized evaluations of (1) Limbsparing surgery plus radiation therapy compared with amputation; (2) The role of adjuvant chemotherapy. Ann Surg 196:305–315PubMedCrossRefGoogle Scholar
Yang JC, Chang AE, Baker AR et al (1998) Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity. J Clin Oncol 16:197–203PubMedGoogle Scholar
Peat BG, Bell RS, Davis A et al (1994) Wound healing complications after soft tissue sarcoma surgery. Plastic Reconstr Surg 93:980–987CrossRefGoogle Scholar
Kunisada T, Ngan SY, Powell G, Choong PFM (2002) Wound complications following pre-operative radiotherapy for soft tissue sarcoma. Eur J Surg Oncol 28:75–79PubMedCrossRefGoogle Scholar
Bell RS, O’sullivan B, Nguyen C et al (1991) Fractures following limb-salvage surgery and adjuvant irradiation for soft-tissue sarcoma. Clin Orthop 271:265–271PubMedGoogle Scholar
Lin PP, Schupak KD, Boland PJ et al (1998) Pathologic femoral fracture after periosteal excision and radiation for the treatment of soft tissue sarcoma. Cancer 82:2356–2365PubMedCrossRefGoogle Scholar
Scherk A, Conill C, Giralt J, Salvador L (1986) Post-irradiation osteosarcoma: a propos of a case. Med Clin (Barc) 87:649Google Scholar
Parker RG, Berry HC (1976) Late effects of therapeutic irradiation on the skeleton and bone marrow. Cancer 37:1162–1171PubMedCrossRefGoogle Scholar
Hong L, Alektiar KM, Hunt M et al (2004) Intensity-modulated radiotherapy for soft tissue sarcoma of the thigh. Int J Radiat Oncol Biol Phys 59:752–759PubMedCrossRefGoogle Scholar
van Duyn EB, Werker PM, van der Werken C (2001) Free vascularised fibula transplantation for treatment of a fractured femur after radiation therapy. Injury 32:82–86PubMedCrossRefGoogle Scholar