Clinical and Translational Oncology

, Volume 9, Issue 8, pp 531–536 | Cite as

Analysis of fiducial markers used for on-line verification in the external-beam radiotherapy of patients with cranial tumours

  • R. M. CañónEmail author
  • I. Azinovic
  • M. Lobato
  • J. Navarro
  • J. Rebollo
Research Articles



Evaluate the fiducial marker-based position verification in the external-beam radiotherapy of patients with cranial tumour.


Thirteen patients with intracranial tumours were treated with external-beam radiotherapy using 3 gold markers implanted in the skull. Before each fraction the patient was positioned on the treatment table and 2 orthogonal portal images were performed to localise the 3 gold seeds and the target position was calculated using a commercialised computer program (ISOLOC software, MEDTEC). This program provides the couch movements required to move the target to the isocentre.


When the set-up error was corrected using the coordinates of the 3 markers, the final movements were less than 2 mm in all cases: lateral, mean v., 1.21 mm; longitudinal, 1.23 mm; and anteroposterior, 1.18 mm. No serious complications related to the gold marker insertion were noted.


The use of 3 implanted fiducial seeds is an optimal technique for precise set-up in patients with brain tumours treated with external radiotherapy. This commercial system is highly suitable for fractionated stereotactic irradiation.

Key words

Fiducial markers Stereotactic radiosurgery Cranial tumour On-line localisation 


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Copyright information

© Feseo 2007

Authors and Affiliations

  • R. M. Cañón
    • 1
    Email author
  • I. Azinovic
    • 1
  • M. Lobato
    • 1
  • J. Navarro
    • 2
  • J. Rebollo
    • 3
  1. 1.Oncología Radioterápica. Plataforma de OncologíaUSP Hospital San JaimeTorrevieja, AlicanteSpain
  2. 2.Servicio de NeurocirugíaUSP Hospital San JaimeTorrevieja, AlicanteSpain
  3. 3.Oncología Médica. Plataforma de OncologíaUSP Hospital San JaimeTorrevieja, AlicanteSpain

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