Abstract
Osteonecrosis of the jaws (ONJ) is a recognized complication of bisphosphonates (BP) therapy in cancer patients with bone metastasis. We report 2 additional cases of ONJ in women with breast cancer after long-term exposure to BP, discussing some considerations about the presentation and management of this rare and new complication.
Similar content being viewed by others
References
Hillner BE, Ingle JN, Berenson JR, et al. American Society of Clinical Oncology guidelines on the role of biphosphonates in breast cancer. J Clin Oncol. 2000;18:1378–91.
Berenson JR, Hillner BE, Kyle RA, et al. American Society of, Clinical Oncology practice guidelines: The role of biphosphonates in multiple myeloma. J Clin Oncol. 2002;20:3719–36.
Rosen LS, Gordon D, Tchekmedyian S, et al. Zoledronic acid versus placebo in the treatment of skeletal metastases in patients with lung cancer and other solid tumors: A phase III, double-blind, randomized trial-the Zoledronic Acid Lung Cancer and Other solid Tumors Study Group. J Clin Oncol. 2003;21:3150–7.
Marx RE. Pamidronate (Aredia) and zole-dronate (Zometa) induced avascular necrosis of the jaws: A growing epidemic. J Oral Maxillofac Surg. 2005;61:1115–7.
Bamias A, Kastritis E, Bamia C, et al. Osteonecrosis of the jaw in cancer after treatment with biphosphonates: Incidence and risk factors. J Clin Oncol. 2005;23:8580–7.
Badros A, Weikel D, Salama A, et al. Osteonecrosis of the jaw, in multiple myeloma patients: Clinical features and risk factors. J Clin Oncol. 2006;24:945–52.
Marx RE, Sawatari Y, Fortin M, Broumand V. Bisphosphonates-induced exposed bone (osteonecrosis/osteopetrosis) of the jaws: Risk factors, recognition, prevention, and treatment. J Oral Maxillofac Surg. 2005;63:1567–75.
Ruggiero SL, Mehrotra B, Rosenberg TJ, Engroff SL. Osteonecrosis of the jaws associated with the use of bisphosphonates: A review of 63 cases. J Oral Maxillofac Surg. 2004;62:527–34.
Rugiero S, Gralow J, Marx RE, et al. Practical guidelines for the prevention, diagnosis, and treatment of osteonecrosis of the jaw in patients with cancer. J Oncol Pract. 2006;2:7–14.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Bujanda, D.A., Cabrera Suárez, M.Á., Sarmiento, U.B. et al. Osteonecrosis of the jaws in patients with bone metastasis receiving intravenous bisphosphonates. A rising concern. Clin Transl Oncol 8, 919–921 (2006). https://doi.org/10.1007/s12094-006-0157-y
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s12094-006-0157-y