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Potentiation of Antibiotic Activity by a Meldrum’s Acid Arylamino Methylene Derivative against Multidrug-Resistant Bacterial Strains

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Abstract

This study aimed to evaluate the intrinsic antibacterial activity and antibiotic-enhancing effect of an arylamino methylene derivative (MAD) in association with fluoroquinolones. The antibacterial activity against multiresistant Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli was analyzed by determining the minimum inhibitory concentration (MIC) using the broth micro dilution method. A reduction in the MIC of the fluoroquinolones against strains treated simultaneously with the MAD was interpreted as an enhanced antibiotic activity. While the MAD exhibited no clinically effective action (MIC ≥ 1.024 µg/mL), it was found to significantly potentiate the activity of norfloxacin, ofloxacin and lomefloxacin against all the strains, which may be related to structural similarities between the MAD and quinolones. Our findings suggest that Meldrum’s acid arylamino derivatives may represent promising molecules in the elaboration of new drugs to reverse resistance to fluoroquinolones.

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Funding

This study was financed in part by the National Council of Scientific and Technological Development—CNPq. Process (150456/2018-2 and 406685/2018-5)

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Authors and Affiliations

  1. Laboratory of Microbiology and Molecular Biology (LMBM), Department of Biological Chemistry, Regional University of Cariri—URCA, Rua Cel. Antonio Luiz, 1161. Pimenta, Crato, CE, CEP: 63105-000, Brazil

    Maria M. C. da Silva, José B. de Araújo-Neto, Ana C. J. de Araújo, Priscilla R. Freitas, Cícera D. de M. Oliveira-Tintino, Henrique D. M. Coutinho & Saulo R. Tintino

  2. Postgraduate Program in Sustainable Territorial Development—Coastal Sector, Federal University of Paraná—UFPR, Curitiba, Brazil

    Luiz E. da Silva

  3. Department of Chemistry, Regional University of Blumenau—FURB, Blumenau, Brazil

    Iêda M. Begnini, Ricardo A. Rebelo, Sandro L. Mireski, Michele C. Nasato & Maria I. L. Krautler

  4. Laboratory of Investigation in Genetics and Translational Hematology, Gonçalo Moniz Institute, Oswaldo Cruz Foundation—IGM-FIOCRUZ/BA, Salvador, BA, Brazil

    Jaime Ribeiro-Filho

Authors
  1. Maria M. C. da Silva
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  2. José B. de Araújo-Neto
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  3. Ana C. J. de Araújo
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  4. Priscilla R. Freitas
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  5. Cícera D. de M. Oliveira-Tintino
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  6. Iêda M. Begnini
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  7. Ricardo A. Rebelo
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  8. Luiz E. da Silva
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  9. Sandro L. Mireski
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  10. Michele C. Nasato
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  11. Maria I. L. Krautler
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  12. Jaime Ribeiro-Filho
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  13. Henrique D. M. Coutinho
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  14. Saulo R. Tintino
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Corresponding author

Correspondence to Henrique D. M. Coutinho.

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da Silva, M.M.C., de Araújo-Neto, J.B., de Araújo, A.C.J. et al. Potentiation of Antibiotic Activity by a Meldrum’s Acid Arylamino Methylene Derivative against Multidrug-Resistant Bacterial Strains. Indian J Microbiol 61, 100–103 (2021). https://doi.org/10.1007/s12088-020-00910-6

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  • DOI: https://doi.org/10.1007/s12088-020-00910-6

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