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Commentary: Reconciling Hygiene and Cleanliness: A New Perspective from Human Microbiome

Indian Journal of Microbiology volume 60, pages 259–261 (2020)Cite this article

Abstract

Human beings have co-evolved with the microorganisms in our environment for millions of years, and have developed into a symbiosis in a mutually beneficial/defensive way. Human beings have significant multifaceted relationships with the diverse microbial community. Apart from the important protective role of microbial community exposure in development of early immunity, millions of inimitable bacterial genes of the diverse microbial community are the indispensable source of essential nutrients like essential amino acids and essential fatty acids for human body. The essential nutrition from microbiome is harvested through xenophagy. As an immune effector, xenophagy will capture any microorganisms that touch the epithelial cells of our gastrointestinal tract, degrade them and turn them into nutrients for the use of our body.

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References

  1. Gupta V, Kumar R, Sood U, Singhvi N (2020) Reconciling hygiene and cleanliness: a new perspective from human microbiome. Indian J Microbiol 60:37–44. https://doi.org/10.1007/s12088-019-00839-5

    Article  PubMed  Google Scholar 

  2. Sender R, Fuchs S, Milo R (2016) Revised estimates for the number of human and bacteria cells in the body. PLoS Biol 14:e1002533. https://doi.org/10.1371/journal.pbio.1002533

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Singhvi N, Gupta V, Gaur M, Sharma V, Puri A, Singh Y, Pandey GD, Lal R (2020) Interplay of human gut microbiome in health and wellness. Indian J Microbiol 60:26–36. https://doi.org/10.1007/s12088-019-00825-x

    Article  CAS  PubMed  Google Scholar 

  4. Kumar R, Sood U, Gupta V, Singh M, Scaria J, Lal R (2020) Recent advancements in the development of modern probiotics for restoring human gut microbiome dysbiosis. Indian J Microbiol 60:12–25. https://doi.org/10.1007/s12088-019-00808-y

    Article  CAS  PubMed  Google Scholar 

  5. Gupta V, Sood U, Kumar R, Lai R, Kalia VC (2020) Microbiome: a new lease to microbiology. Indian J Microbiol 60:1. https://doi.org/10.1007/s12088-019-00852-8

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Sood U, Gupta V, Kumar R, Lal S, Fawcett D, Rattan S, Poinern EDJ, Lal R (2020) Chicken gut microbiome and human health: past scenarios, current perspectives, and futuristic applications. Indian J Microbiol 60:2–11. https://doi.org/10.1007/s12088-019-00785-2

    Article  PubMed  Google Scholar 

  7. Hristov KK (2019) Gastrointestinal microbiota and immunity. J IMAB 25:2683–2688. https://doi.org/10.5272/jimab.2019253.2683

    Article  Google Scholar 

  8. Novik G, Savich V (2020) Beneficial microbiota. Probiotics and pharmaceutical products in functional nutrition and medicine. Microbes Infect 22:8–18. https://doi.org/10.1016/j.micinf.2019.06.004

    Article  CAS  PubMed  Google Scholar 

  9. Wang B, Yao M, Lv L, Ling Z, Li L (2017) The human microbiota in health and disease. Engineering 3:71–82. https://doi.org/10.1016/J.ENG.2017.01.008

    Article  Google Scholar 

  10. Liwinski T, Elinav E (2019) Harnessing the microbiota for therapeutic purposes. Am J Transpl. https://doi.org/10.1111/ajt.15753(Article in Press)

    Article  Google Scholar 

  11. Clark JH, Klusmeyer TH, Cameron MR (1992) Microbial protein-synthesis and flows of nitrogen fractions to the duodenum of dairy-cows. J Dairy Sci 75:2304–2323. https://doi.org/10.3168/jds.S0022-0302(92)77992-2

    Article  CAS  PubMed  Google Scholar 

  12. Bach A, Calsamiglia S, Stern MD (2005) Nitrogen metabolism in the rumen. J Dairy Sci 88:E9–E21. https://doi.org/10.3168/jds.S0022-0302(05)73133-7

    Article  PubMed  Google Scholar 

  13. Tamang JP, Shin DH, Jung SJ, Chae SW (2016) Functional properties of microorganisms in fermented foods. Front Microbiol 7:578. https://doi.org/10.3389/fmicb.2016.00578

    Article  PubMed  PubMed Central  Google Scholar 

  14. Chassard C, Delmas E, Robert C, Bernalier-Donadille A (2010) The cellulose-degrading microbial community of the human gut varies according to the presence or absence of methanogens. FEMS Microbiol Ecol 74:205–213. https://doi.org/10.1111/j.1574-6941.2010.00941.x

    Article  CAS  PubMed  Google Scholar 

  15. Nair MRB, Chouhan D, Gupta SS, Chattopadhyay S (2016) Fermented foods: are they tasty medicines for helicobacter pylori associated peptic ulcer and gastric cancer? Front Microbiol 7, 1148. https://doi.org/10.3389/fmicb.2016.01148

    Article  PubMed  PubMed Central  Google Scholar 

  16. Mota de Carvalho N, Costa EM, Silva S, Pimentel L, Fernandes TH, Estevez Pintado M (2018) Fermented foods and beverages in human diet and their influence on gut microbiota and health. Fermentation 4:90. https://doi.org/10.3390/fermentation4040090

    Article  CAS  Google Scholar 

  17. Yu BW, Yu BX, Yu LG (2018). Restore gut homeostasis and healthy weight for an anorexia nervosa Patient by the Luigi Cornaro diet—a case report. Publisher: Institute of Materials (East Asia). ISBN: 978-981-14-0181-7. https://www.researchgate.net/publication/329915614_Book_on_Luigi_Cornaro_Diet_for_An_Anorexia_Nervosa_Patient_-_Simplified_Version

  18. Haq S, Grondin J, Banskota S, Khan WI (2019) Autophagy: roles in intestinal mucosal homeostasis and inflammation. J Biomed Sci 26, 19. https://doi.org/10.1186/s12929-019-0512-2

    Article  PubMed  PubMed Central  Google Scholar 

  19. Zhi XY, Feng WZ, Rong YG, Liu R (2018) Anatomy of autophagy: from the beginning to the end. Cell Mol Life Sci 75:815–831. https://doi.org/10.1007/s00018-017-2657-z

    Article  CAS  PubMed  Google Scholar 

  20. Eskelinen EL, Saftig P (2009) Autophagy: a lysosomal degradation pathway with a central role in health and disease. Biochimica et Biophysica Acta-Molecular Cell Research 1793:664–673. https://doi.org/10.1016/j.bbamcr.2008.07.014

    Article  CAS  Google Scholar 

  21. Levine B, Kroemer G (2008) Autophagy in the pathogenesis of disease. Cell 132:27–42. https://doi.org/10.1016/j.cell.2007.12.018

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Allen A, Snary D (1972) The structure and function of gastric mucus. Prog Rep Gut 13:666–672. https://doi.org/10.1136/gut.13.8.666

    Article  CAS  Google Scholar 

  23. van Niekerk G, Loos B, Nell T, Engelbrecht AM (2016) Autophagy—a free meal in sickness-associated anorexia. Autophagy 12:727–734. https://doi.org/10.1080/15548627.2016.1147672

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. van Niekerk G, Isaacs AW, Nell T, Engelbrecht AM (2016) Sickness-associated anorexia: mother nature's idea of immunonutrition? Mediat Inflamm 216, 8071539. https://doi.org/10.1155/2016/8071539

    Article  CAS  Google Scholar 

  25. Kuballa P, Nolte WM, Castoreno AB, Xavier RJ (2012) Autophagy and the immune system. Annu Rev Immunol 30:611–646. https://doi.org/10.1146/annurev-immunol-020711-074948

    Article  CAS  PubMed  Google Scholar 

  26. Jo EK, Yuk JM, Shin DM, Sasakawa C (2013) Roles of autophagy in elimination of intracellular bacterial pathogens. Front Immunol 4, UNSP 97. https://doi.org/10.3389/fimmu.2013.00097

    Article  CAS  Google Scholar 

  27. Gomes LC, Dikic I (2014) Autophagy in antimicrobial immunity. Mol Cell 54:224–233. https://doi.org/10.1016/j.molcel.2014.03.009

    Article  CAS  PubMed  Google Scholar 

  28. Randall-Demllo S, Chieppa M, Eri R (2013) Intestinal epithelium and autophagy: partners in gut homeostasis. Front Immunol 4(3):301. https://doi.org/10.3389/fimmu.2013.00301

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Kabat AM, Pott J, Maloy KJ (2016) The mucosal immune system and its regulation by autophagy. Front Immunol 7:240. https://doi.org/10.3389/fimmu.2016.00240

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Anagnostou C, LeGrand EA, Rohlfs M (2010) Friendly food for fitter flies? Influence of dietary microbial species on food choice and parasitoid resistance in Drosophila. Oikos 119:533–541. https://doi.org/10.1111/j.1600-0706.2009.18001.x

    Article  Google Scholar 

  31. Akami M, Andongma AA, Chen ZZ, Nan J, Khaeso K, Jurkevitch E, Niu CY, Yuval B (2019) Intestinal bacteria modulate the foraging behavior of the oriental fruit fly Bactrocera dorsalis (Diptera: Tephritidae). PLoS ONE 14, e0210109. https://doi.org/10.1371/journal.pone.0210109

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Hwa Chong Institution, Singapore, Singapore

    Boxuan Yu

  2. School of Computing, National University of Singapore, Singapore, Singapore

    Bowei Yu

  3. Talent Recruitment and Career Support (TRACS) Office, Nanyang Technological University, Singapore, Singapore

    Ligen Yu

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  1. Boxuan Yu
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  2. Bowei Yu
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  3. Ligen Yu
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Correspondence to Ligen Yu.

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Yu, B., Yu, B. & Yu, L. Commentary: Reconciling Hygiene and Cleanliness: A New Perspective from Human Microbiome. Indian J Microbiol 60, 259–261 (2020). https://doi.org/10.1007/s12088-020-00863-w

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  • DOI: https://doi.org/10.1007/s12088-020-00863-w

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