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Synthesis, Antimicrobial and Antioxidant Activity of Pyrazole Based Sulfonamide Derivatives

Indian Journal of Microbiology volume 58, pages 93–99 (2018)Cite this article

Abstract

A series of new sulfonamides have been synthesized from Ampyrone with different benzene sulfonyl chlorides to yield the N-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl) benzenesulfonamides (4a–e). All synthesized compounds were characterized on the basis of FTIR, 1H NMR, and 13C NMR, and also by the aid of mass spectral data. Further, all synthesized compounds have studied for their in vitro antimicrobial activities against selected bacterial as well as fungal strains by the agar well diffusion method. Free radical scavenging activity has been investigated by using DPPH method. Among all the synthesized compounds, 4b, 4d, and 4e exhibited significant antimicrobial and antioxidant activities.

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Acknowledgements

We are thankful to the University Grants Commission (UGC), New Delhi for finical assistance under UGC—BSR fellowship scheme.

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Affiliations

  1. School of Chemical Sciences, North Maharashtra University, Jalgaon, 425001, India

    Jagdish R. Badgujar & Dhananjay H. More

  2. Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, 440033, India

    Jyotsna S. Meshram

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  1. Jagdish R. Badgujar
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  2. Dhananjay H. More
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Correspondence to Jagdish R. Badgujar.

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Badgujar, J.R., More, D.H. & Meshram, J.S. Synthesis, Antimicrobial and Antioxidant Activity of Pyrazole Based Sulfonamide Derivatives. Indian J Microbiol 58, 93–99 (2018). https://doi.org/10.1007/s12088-017-0689-6

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Keywords

  • Pyrazols
  • Ampyrone
  • Sulfonamide
  • Antimicrobial activity
  • Antioxidant activity