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Targeted Metagenome Based Analyses Show Gut Microbial Diversity of Inflammatory Bowel Disease patients

Indian Journal of Microbiology volume 57, pages 307–315 (2017)Cite this article

Abstract

Inflammatory bowel disease (IBD) is a multifactorial disease including both genetic and environmental factors. We compared the diversity of intestinal microbesamong a cohort of IBD patients to study the microbial ecological effects on IBD. Fecal samples from patients were sequenced with next generation sequence technology at 16S rDNA region. With statistical tools, microbial community was investigated at different level. The gut microbial diversity of Crohn’s disease (CD) patients and colonic polyp (CP) patients significantly different from each other. However, the character of ulcerative colitis (UC) patients has of both CD and CP features. The microbial community from IBD patients can be very different (CD patient) or somewhat similar (UC patients) to non-IBD patients. Microbial diversity can be an important etiological factor for IBD clinical phenotype.

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Acknowledgements

This work was supported by Grants from the Shanghai Municipal Commission of Health and Family Planning (No. 20124011), the Shanghai Municipal Commission of Health and Family Planning (No. 20164Y0153).

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Authors and Affiliations

  1. Department of Digestive Diseases, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Rd., Shanghai, 200040, China

    Zhibing Qiu, Haijing Yang, Lan Rong, Weiqun Ding & Liang Zhong

  2. Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China

    Jiazhen Chen

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  1. Zhibing Qiu
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  2. Haijing Yang
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  3. Lan Rong
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Correspondence to Liang Zhong.

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Qiu, Z., Yang, H., Rong, L. et al. Targeted Metagenome Based Analyses Show Gut Microbial Diversity of Inflammatory Bowel Disease patients. Indian J Microbiol 57, 307–315 (2017). https://doi.org/10.1007/s12088-017-0652-6

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  • DOI: https://doi.org/10.1007/s12088-017-0652-6

Keywords

  • Microbial diversity
  • 16S rDNA
  • Inflammatory bowel disease (IBD)
  • Statistical analysis