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Indian Journal of Microbiology

, Volume 57, Issue 3, pp 307–315 | Cite as

Targeted Metagenome Based Analyses Show Gut Microbial Diversity of Inflammatory Bowel Disease patients

  • Zhibing Qiu
  • Haijing Yang
  • Lan Rong
  • Weiqun Ding
  • Jiazhen Chen
  • Liang ZhongEmail author
Original Article

Abstract

Inflammatory bowel disease (IBD) is a multifactorial disease including both genetic and environmental factors. We compared the diversity of intestinal microbesamong a cohort of IBD patients to study the microbial ecological effects on IBD. Fecal samples from patients were sequenced with next generation sequence technology at 16S rDNA region. With statistical tools, microbial community was investigated at different level. The gut microbial diversity of Crohn’s disease (CD) patients and colonic polyp (CP) patients significantly different from each other. However, the character of ulcerative colitis (UC) patients has of both CD and CP features. The microbial community from IBD patients can be very different (CD patient) or somewhat similar (UC patients) to non-IBD patients. Microbial diversity can be an important etiological factor for IBD clinical phenotype.

Keywords

Microbial diversity 16S rDNA Inflammatory bowel disease (IBD) Statistical analysis 

Notes

Acknowledgements

This work was supported by Grants from the Shanghai Municipal Commission of Health and Family Planning (No. 20124011), the Shanghai Municipal Commission of Health and Family Planning (No. 20164Y0153).

Supplementary material

12088_2017_652_MOESM1_ESM.rar (73 kb)
Supplementary material 1 (RAR 73 kb)

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Copyright information

© Association of Microbiologists of India 2017

Authors and Affiliations

  1. 1.Department of Digestive Diseases, Huashan HospitalFudan UniversityShanghaiChina
  2. 2.Department of Infectious Diseases, Huashan HospitalFudan UniversityShanghaiChina

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