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Biomedical Applications of Polyhydroxyalkanoates

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Abstract

Polyhydroxyalkanoates (PHA) are produced by a large number of microbes under stress conditions such as high carbon (C) availability and limitations of nutrients such as nitrogen, potassium, phosphorus, magnesium, and oxygen. Here, microbes store C as granules of PHAs—energy reservoir. PHAs have properties, which are quite similar to those of synthetic plastics. The unique properties, which make them desirable materials for biomedical applications is their biodegradability, biocompatibility, and non-toxicity. PHAs have been found suitable for various medical applications: biocontrol agents, drug carriers, biodegradable implants, tissue engineering, memory enhancers, and anticancer agents.

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Abbreviations

PHA:

Polyhydroxyalkanoate

PHB:

Polyhydroxybutyrate

3HB:

3-Hydroxybutyric acid

3HV:

3-Hydroxyvaleric acid

3HO:

3-Hydroxyoctanoate

3HD:

3-Hydroxydecanoic acid

4HB:

4-Hydroxybutyric acid

P(3HB-3HV):

Poly-3hydroxybutyrate-co-3hydroxyvalerate

P(3HB-4HB-3HV):

Poly-3hydroxybutyrate-co-4hydroxybutyrate-co-3hydroxyvalerate

P(3HB-3HV-3HHx):

Poly-3hydroxybutyrate-co-3hydroxyvalerate-co-3hydroxyhexanoate

P(3HB-3HO):

Poly-3hydroxybutyrate-co-3hydroxyoctanoate

P(3HB-3HV-DHB):

Poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-2,3-dihydroxybutyrate)

3HA:

Hydroxyalkanoic acid

OA:

Octanoic acid

UA:

Undecanoic acid

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Acknowledgements

The authors wish to thank the Director of CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), CSIR-HRD project OLP1126 (ES Scheme No. 21(1022)/16/EMR-2), Delhi, India, for providing the necessary funds, facilities and moral support. Authors are also thankful to Academy of Scientific & Innovative Research (AcSIR), New Delhi.

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  1. Microbial Biotechnology and Genomics, CSIR - Institute of Genomics and Integrative Biology (IGIB), Delhi University Campus, Mall Road, Delhi, 110007, India

    Subhasree Ray & Vipin Chandra Kalia

  2. Academy of Scientific and Innovative Research (AcSIR), 2, Rafi Marg, Anusandhan Bhawan, New Delhi, 110001, India

    Subhasree Ray & Vipin Chandra Kalia

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Ray, S., Kalia, V.C. Biomedical Applications of Polyhydroxyalkanoates. Indian J Microbiol 57, 261–269 (2017). https://doi.org/10.1007/s12088-017-0651-7

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