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Theoretical Ecology

, Volume 9, Issue 4, pp 431–442 | Cite as

Vaccine-driven evolution of parasite virulence and immune evasion in age-structured population: the case of pertussis

  • Veronika Bernhauerová
ORIGINAL PAPER

Abstract

Despite enormous success of mass immunization programs in reducing incidence of infectious diseases, vaccine-escape strains have emerged perhaps as a consequence of strong selection pressures exerted on parasites by vaccines. Pertussis presents a well-documented example. As a childhood infection, it exhibits age-specific transmission biased to children. Assuming different transmission rates between children and adults, I study, by means of an age-structured epidemic model, evolutionary dynamics of parasite virulence in a vaccinated population. I find that the age-structure does not affect the evolutionary dynamics of parasite virulence. Also, based on empirical data reporting antigenic divergence with vaccine strains and mutations in virulence-associated genes in pertussis populations, I allow for parallel occurrence of mutations in parasite virulence and associated immune evasion. I conclude that this simultaneous adaptation of both traits may substantially alter the evolutionary course of the parasite. In particular, higher values of virulence are favoured once the parasite is able to evade the transmission-blocking vaccine-induced immunity. On the other hand, lower values of virulence are selected for once the parasite evolves the ability to evade the virulence-blocking vaccine-induced immunity. I emphasize the importance of multi-trait evolution to assess the direction of parasite adaptation more accurately.

Keywords

Age-structured model Adaptive dynamics Bordetella pertussis Immune evasion Vaccination Virulence 

Notes

Acknowledgments

I would like to acknowledge institutional support MUNI/A/1441/2014 Student Project Grant at MU. I thank two anonymous reviewers for their suggestions that helped to improve the exposition of this paper. I would also like to thank Pejman Rohani for giving me the opportunity to work on this project and Luděk Berec for his comments on the manuscript.

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Copyright information

© Springer Science+Business Media Dordrecht 2016

Authors and Affiliations

  1. 1.Department of Mathematics and Statistics, Faculty of ScienceMasaryk UniversityBrnoCzech Republic
  2. 2.Department of Infectious DiseasesSt. Jude Children’s Research HospitalMemphisUSA

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