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Biological functions of CRTC2 and its role in metabolism-related diseases

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Journal of Cell Communication and Signaling Aims and scope

Abstract

CREB-regulated transcription coactivator2 (CRTC2 or TORC2) is a transcriptional coactivator of CREB(cAMP response element binding protein), which affects human energy metabolism through cyclic adenosine phosphate pathway, Mammalian target of rapamycin (mTOR) pathway, Sterol regulatory element binding protein 1(SREBP1), Sterol regulatory element binding protein 2 (SREBP2) and other substances Current studies on CRTC2 mainly focus on glucose and lipid metabolism, relevant studies show that CRTC2 can participate in the occurrence and development of related diseases by affecting metabolic homeostasis. It has been found that Crtc2 acts as a signaling regulator for cAMP and Ca2 + signaling pathways in many cell types, and phosphorylation at ser171 and ser275 can regulate downstream biological functions by controlling CRTC2 shuttling between cytoplasm and nucleus.

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Acknowledgements

This work was supported by National Natural Science Foundation of China (81670429, 91839103 to ZSJ), International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province (2018WK4031), Special Funding for Construction of Innovative Provinces in Hunan Province (2020SK2105, to ZSJ) and “Double First-Class” project for innovative Group of Basic Medicine, University of South China (to ZSJ).

Funding

National Natural Science Foundation of China, 81670429, zhisheng jiang, 91839103, zhisheng jiang, International Joint Laboratory for MicroNano Manufacturing and Measurement Technologies, 2018WK4031, zhisheng jiang, Special Funding for Construction of Innovative Provinces in Hunan Province, 2020SK2105, zhisheng jiang, “Double First-Class” project for innovative Group of Basic Medicine, University of South China.

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  1. Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province, University of South China, Hengyang, 421001, China

    Hong-Yu Zheng, Yan-Xia Wang, Kun Zhou, Hai-Lin Xie, Zhong Ren, Hui-Ting Liu, Yang-Shao Ou, Zhi-Xiang Zhou & Zhi-Sheng Jiang

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Zheng, HY., Wang, YX., Zhou, K. et al. Biological functions of CRTC2 and its role in metabolism-related diseases. J. Cell Commun. Signal. 17, 495–506 (2023). https://doi.org/10.1007/s12079-023-00730-5

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