Exosomes and autophagy: rekindling the vesicular waste hypothesis

Gudbergsson, Johann Mar; Johnsen, Kasper Bendix

doi:10.1007/s12079-019-00524-8

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Published: 06 June 2019

Exosomes and autophagy: rekindling the vesicular waste hypothesis

Journal of Cell Communication and Signaling volume 13, pages 443–450 (2019)Cite this article

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Abstract

Exosomes were first described as waste carriers implicated in reticulocyte maturation but has during the past decade been associated with many other cellular functions. The biogenesis of exosomes has been extensively studied and several protein machineries have been identified to dictate their production and release. The newly discovered branches of the autophagy system implicate secretion of waste in endosomal-derived vesicles as is thought for exosome release. Many of the proteins that have been identified as responsible for the formation and release of these vesicles are the same as those identified in exosome biogenesis. In this Perspective, we discuss the possibility of exosomes being a part of the autophagy machinery and the consequences this could have on interpretation of exosome functions.

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Department of Health Science and Technology, Laboratory of Immunology and Cancer Biology, Aalborg University, Fredrik Bajers Vej 3B, 9220, Aalborg, Denmark
Johann Mar Gudbergsson
Department of Health Technology, Center for Nanomedicine and Theranostics, Technical University of Denmark, Kongens Lyngby, Denmark
Kasper Bendix Johnsen

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Johann Mar Gudbergsson
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Gudbergsson, J.M., Johnsen, K.B. Exosomes and autophagy: rekindling the vesicular waste hypothesis. J. Cell Commun. Signal. 13, 443–450 (2019). https://doi.org/10.1007/s12079-019-00524-8

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Received: 04 April 2019
Accepted: 31 May 2019
Published: 06 June 2019
Issue Date: December 2019
DOI: https://doi.org/10.1007/s12079-019-00524-8

Keywords

Exosomes
Extracellular vesicles
Autophagy
Secretory autophagy
EV
Vesicles