Skip to main content
Log in

Hormesis: from mainstream to therapy

  • Research Article
  • Published:
Journal of Cell Communication and Signaling Aims and scope

Abstract

This issue of the Journal of Cell Communication and Cell Signaling on hormetic mechanisms represents an important step in the evolution of the hormesis dose response concept. Since its modern resurgence in the late 1970s the widespread occurrence of hormesis has been in search of its underlying mechanisms. The present integrative set of papers builds upon significant recent advances in the elucidation of hormetic mechanisms and provides the reader with a deep and extensive view of the concept of hormesis from a broad range of researcher perspectives and in many biomedical applications.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  • Calabrese EJ (2005) Historical blunders: how toxicology got the dose-response relationship half right. Cell Mol Biol 51(7):643–654

    CAS  PubMed  Google Scholar 

  • Calabrese EJ (2008) Hormesis: why it is important to toxicology and toxicologists. Environ Toxicol Chem 27(7):1451–1474

    Article  CAS  PubMed  Google Scholar 

  • Calabrese EJ (2013) Hormesis mechanisms. Crit Rev Toxicol 43(7):580–606

    Article  CAS  PubMed  Google Scholar 

  • Calabrese EJ, Baldwin LA (2000a) Chemical hormesis: its historical foundations as a biological hypothesis. Hum Exp Toxicol 19(1):2–31

    Article  CAS  PubMed  Google Scholar 

  • Calabrese EJ, Baldwin LA (2000b) The marginalization of hormesis. Hum Exp Toxicol 19(1):32–40

    Article  CAS  PubMed  Google Scholar 

  • Calabrese EJ, Baldwin LA (2000c) Radiation hormesis: its historical foundations as a biological hypothesis. Hum Exp Toxicol 19(1):41–75

    Article  CAS  PubMed  Google Scholar 

  • Calabrese EJ, Baldwin LA (2000d) Radiation hormesis: the demise of a legitimate hypothesis. Hum Exp Toxicol 19(1):76–84

    Article  CAS  PubMed  Google Scholar 

  • Calabrese EJ, Baldwin LA (2000e) Tales of two similar hypotheses: the rise and fall of chemical and radiation hormesis. Hum Exp Toxicol 19(1):85–97

    Article  CAS  PubMed  Google Scholar 

  • Calabrese EJ, Baldwin LA (2002) Defining hormesis. Hum Exp Toxicol 21(2):91–97

    Article  CAS  PubMed  Google Scholar 

  • Calabrese EJ, Baldwin LA (2003) The hormetic dose-response model is more common than the threshold model in toxicology. Toxicol Sci 71(2):246–250

    Article  CAS  PubMed  Google Scholar 

  • Calabrese EJ, Blain R (2005) The occurrence of hormetic dose responses in the toxicological literature, the hormesis database: an overview. Toxicol Appl Pharmacol 202(3):289–301

    Article  CAS  PubMed  Google Scholar 

  • Calabrese EJ, Blain RB (2009) Hormesis and plant biology. Environ Poll 157(1):42–48

    Article  CAS  Google Scholar 

  • Calabrese EJ, Blain RB (2011) The hormesis database: the occurrence of hormetic dose responses in the toxicological literature. Reg Toxicol Pharmacol 61(1):73–81

    Article  CAS  Google Scholar 

  • Crump T (2003) Contemporary medicine as presented by its practitioners themselves. Leipzig 1923:217–250. Hugo Schulz, NIH Library Translation (NIH-98-134). Nonlinear Biol Toxicol Med 1:295–318

  • Luckey TD (1980) Ionizing radiation and hormesis. CRC Press, Boca Raton

    Google Scholar 

  • Schulz H (1887) Zur Lehre von der Arzneiwirdung. Virchows Arch Pathol Anat Physiol Fur Klin Med 108:423–445

    Article  Google Scholar 

  • Schulz H (1888) Uber Hefegifte. Pflugers Arch Gesamte Physiol Mensch Tiere 42:517–541

    Article  Google Scholar 

  • Southam CM, Ehrlich J (1943) Effects of extract of western red-cedar heartwood on certain wood-decaying fungi in culture. Phytopathology 33(6):517–524

    Google Scholar 

  • Stebbing ARD (1981) Hormesis: stimulation of colony growth in campanularia-flexuosa (hydrozoa) by copper, cadmium and other toxicants. Aquat Toxicol 1(3–4):227–238

    Article  CAS  Google Scholar 

  • Stebbing ARD (1998) A theory for growth hormesis. Mut Res 403(1–2):249–258

    Article  CAS  Google Scholar 

  • Szabadi E (1977) Model of 2 functionally antagonistic receptor populations activated by same agonist. J Theor Biol 69(1):101–112

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

Research activities in the area of dose response have been funded by the United States Air Force and ExxonMobil Foundation over a number of years. However, such funding support has not been used for the present manuscript. The author confirms independence from the sponsors; the content of the article has not been influenced by the sponsors.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Edward J. Calabrese.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Calabrese, E.J. Hormesis: from mainstream to therapy. J. Cell Commun. Signal. 8, 289–291 (2014). https://doi.org/10.1007/s12079-014-0255-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12079-014-0255-5

Keywords

Navigation