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The integrin needle in the stromal haystack: emerging role in corneal physiology and pathology

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Journal of Cell Communication and Signaling Aims and scope

Abstract

Several studies have established the role of activated corneal keratocytes in the fibrosis of the cornea. However, the role of keratocytes in maintaining the structural integrity of a normal cornea is less appreciated. We focus on the probable functions of integrins in the eye and of the importance of integrin-mediated keratocyte interactions with stromal matrix in the maintenance of corneal integrity. We point out that further understanding of how keratocytes interact with their matrix could establish a novel direction in preventing corneal pathology including loss of structural integrity as in keratoconus or as in fibrosis of the corneal stroma.

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  1. Department of Ophthalmology, University of Western Ontario, London, Ontario, N6A 4V2, Canada

    Sunil K. Parapuram & William Hodge

  2. Lawson Health Research Institute, University of Western Ontario, 268 Grosvenor Street, London, Ontario, N6A 4V2, Canada

    Sunil K. Parapuram

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Parapuram, S.K., Hodge, W. The integrin needle in the stromal haystack: emerging role in corneal physiology and pathology. J. Cell Commun. Signal. 8, 113–124 (2014). https://doi.org/10.1007/s12079-014-0230-1

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