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A network map of the gastrin signaling pathway

  • Yashwanth Subbannayya
  • Kumari Anuja
  • Jayshree Advani
  • Urmesh Kumar Ojha
  • Vishalakshi Nanjappa
  • Bijesh George
  • Avinash Sonawane
  • Rekha V. Kumar
  • Girija Ramaswamy
  • Akhilesh Pandey
  • B. L. Somani
  • Rajesh Raju
Nuts and Bolts

Introduction

Gastrin is the primary hormone that induces gastric acid secretion (Edkins 1906). In humans, the gene encoding for gastrin is located on chromosome 17q21 (Lund et al. 1986). This hormone is produced by the G-cells of the antrum of stomach as preprogastrin, which comprises of 101 amino acids and is cleaved between Ala-21 and Ser-22 to yield progastrin (Reeve et al. 1984). Progastrin is then sequentially cleaved by prohormone convertase and carboxypeptidase E to yield glycine-extended gastrins- a 35-amino acid gastrin-34-Gly (G34-Gly) or an 18-amino acid gastrin-17-Gly (G17-Gly) in endocrine cells (Varro et al. 1995; Lacourse et al. 1997). G34-Gly and G17-Gly are amidated at their carboxyl terminal groups by the enzyme peptidyl alpha-amidating mono-oxygenase to form amidated gastrin.

Gastrin interacts with the membrane-bound G-protein coupled cholecystokinin receptor group consisting of Cholecystokinin A receptor (CCKAR) and Cholecystokinin B receptor (CCKBR). CCKAR...

Keywords

Parietal Cell Gastric Acid Secretion Cholecystokinin Atrophic Gastritis Pernicious Anemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

CCKAR

Cholecystokinin A receptor

CCKBR

Cholecystokinin B receptor

ECL

Enterochromaffin-like

PPI

Protein-protein interaction

PTM

Post-translational modification

HPRD

Human protein reference database

SBML

Systems biology markup language

PSI-MI

Proteomics standards initiative for molecular interaction

BioPax

Biological pathway exchange

Notes

Acknowledgements

We thank the Department of Biotechnology, Government of India for research support to the Institute of Bioinformatics, Bangalore. YS is a recipient of Senior Research Fellowship from University Grants Commission (UGC), Government of India.

Conflict of interest

No potential conflict of interest declared.

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Copyright information

© The International CCN Society 2014

Authors and Affiliations

  • Yashwanth Subbannayya
    • 1
    • 2
    • 3
  • Kumari Anuja
    • 4
  • Jayshree Advani
    • 1
  • Urmesh Kumar Ojha
    • 4
  • Vishalakshi Nanjappa
    • 1
  • Bijesh George
    • 1
  • Avinash Sonawane
    • 4
  • Rekha V. Kumar
    • 5
  • Girija Ramaswamy
    • 3
  • Akhilesh Pandey
    • 6
    • 7
    • 8
    • 9
  • B. L. Somani
    • 1
  • Rajesh Raju
    • 1
  1. 1.Institute of BioinformaticsInternational Tech ParkBangaloreIndia
  2. 2.Rajiv Gandhi University of Health SciencesBangaloreIndia
  3. 3.Department of BiochemistryKidwai Memorial Institute of OncologyBangaloreIndia
  4. 4.KIIT School of BiotechnologyKIIT UniversityBhubaneswarIndia
  5. 5.Department of PathologyKidwai Memorial Institute of OncologyBangaloreIndia
  6. 6.McKusick-Nathans Institute of Genetic MedicineJohns Hopkins University School of MedicineBaltimoreUSA
  7. 7.Department of Biological ChemistryJohns Hopkins University School of MedicineBaltimoreUSA
  8. 8.Department of PathologyJohns Hopkins University School of MedicineBaltimoreUSA
  9. 9.Department of OncologyJohns Hopkins University School of MedicineBaltimoreUSA

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