A network map of BDNF/TRKB and BDNF/p75NTR signaling system
Neurotrophic factors are growth factors, which play an essential role in the development and maintenance of nervous system. These include members of the nerve growth factor (NGF) family, known as neurotrophins. Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), neurotrophin 4 (NT4/5) and neurotrophin 6 (NT-6) constitute the family of neurotrophins (Barbacid 1995). The identification of neurotrophic factors began from the search for target-derived molecules, which act on neurons and promote their survival (Lindsay 1996). BDNF is one such essential survival factor.
BDNF was first isolated and purified from pig brain (Barde et al. 1982). BDNF, encoded by the BDNF gene, is the second member of the neurotrophin family after NGF (Timmusk et al. 1993). BDNF, like other neurotrophins, exists as a homodimer. It is synthesized as a precursor molecule, proBDNF (32 kDa), which is cleaved to form the mature and biologically active form of BDNF...
KeywordsNerve Growth Factor Translocation Event BDNF Signaling Software Utility NTRK2 Gene
Brain-derived neurotrophic factor
Nerve growth factor
p75 neurotrophin receptor
Biological PAthway eXchange
Systems Biology Markup Language
Proteomics Standards Initiative for Molecular Interaction
We thank the Department of Biotechnology, Government of India for research support to the Institute of Bioinformatics, Bangalore. Varot K. Sandhya is a recipient of Inspire Fellowship from the Department of Science and Technology (DST), Government of India. Renu Verma is a recipient of Junior Research Fellowship from the University Grants Commission (UGC), Government of India. Rakesh Sharma is a Research Associate supported by the Department of Biotechnology (DBT), Government of India. Aneesha Radhakrishnan is a recipient of Senior Research Fellowship from the Council of Scientific and Industrial Research (CSIR), Government of India. We acknowledge Dr. Renu Goel for her assistance in curation.
Conflict of interests
The author(s) declared no conflicts of interests.
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