Journal of Cell Communication and Signaling

, Volume 7, Issue 4, pp 301–307 | Cite as

A network map of BDNF/TRKB and BDNF/p75NTR signaling system

  • Varot K. Sandhya
  • Rajesh Raju
  • Renu Verma
  • Jayshree Advani
  • Rakesh Sharma
  • Aneesha Radhakrishnan
  • Vishalakshi Nanjappa
  • Jayasuryan Narayana
  • B. L. Somani
  • Kanchan K. Mukherjee
  • Akhilesh Pandey
  • Rita Christopher
  • T. S. Keshava Prasad
Nuts and Bolts


Neurotrophic factors are growth factors, which play an essential role in the development and maintenance of nervous system. These include members of the nerve growth factor (NGF) family, known as neurotrophins. Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), neurotrophin 4 (NT4/5) and neurotrophin 6 (NT-6) constitute the family of neurotrophins (Barbacid 1995). The identification of neurotrophic factors began from the search for target-derived molecules, which act on neurons and promote their survival (Lindsay 1996). BDNF is one such essential survival factor.

BDNF was first isolated and purified from pig brain (Barde et al. 1982). BDNF, encoded by the BDNF gene, is the second member of the neurotrophin family after NGF (Timmusk et al. 1993). BDNF, like other neurotrophins, exists as a homodimer. It is synthesized as a precursor molecule, proBDNF (32 kDa), which is cleaved to form the mature and biologically active form of BDNF...


Nerve Growth Factor Translocation Event BDNF Signaling Software Utility NTRK2 Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Brain-derived neurotrophic factor


Tropomyosin-related kinase


Nerve growth factor




p75 neurotrophin receptor


Protein–protein interactions


Post-translational modifications


Biological PAthway eXchange


Systems Biology Markup Language


Proteomics Standards Initiative for Molecular Interaction



We thank the Department of Biotechnology, Government of India for research support to the Institute of Bioinformatics, Bangalore. Varot K. Sandhya is a recipient of Inspire Fellowship from the Department of Science and Technology (DST), Government of India. Renu Verma is a recipient of Junior Research Fellowship from the University Grants Commission (UGC), Government of India. Rakesh Sharma is a Research Associate supported by the Department of Biotechnology (DBT), Government of India. Aneesha Radhakrishnan is a recipient of Senior Research Fellowship from the Council of Scientific and Industrial Research (CSIR), Government of India. We acknowledge Dr. Renu Goel for her assistance in curation.

Conflict of interests

The author(s) declared no conflicts of interests.


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Copyright information

© The International CCN Society 2013

Authors and Affiliations

  • Varot K. Sandhya
    • 1
  • Rajesh Raju
    • 1
  • Renu Verma
    • 1
    • 2
  • Jayshree Advani
    • 1
  • Rakesh Sharma
    • 1
    • 3
  • Aneesha Radhakrishnan
    • 1
    • 4
  • Vishalakshi Nanjappa
    • 1
    • 5
  • Jayasuryan Narayana
    • 2
  • B. L. Somani
    • 1
  • Kanchan K. Mukherjee
    • 6
  • Akhilesh Pandey
    • 7
  • Rita Christopher
    • 3
  • T. S. Keshava Prasad
    • 1
    • 5
  1. 1.Institute of BioinformaticsInternational Tech ParkBangaloreIndia
  2. 2.Microtest Innovations Pvt. Ltd.BangaloreIndia
  3. 3.Department of NeurochemistryNational Institute of Mental health and NeurosciencesBangaloreIndia
  4. 4.Department of Biochemistry and Molecular BiologyPondicherry UniversityPuducherryIndia
  5. 5.Amrita School of BiotechnologyAmrita Vishwa VidyapeethamKollamIndia
  6. 6.Department of NeurosurgeryPostgraduate Institute of Medical Education & ResearchChandigarhIndia
  7. 7.McKusick-Nathans Institute of Genetic Medicine and Departments of Biological Chemistry, Pathology and OncologyJohns Hopkins University School of MedicineBaltimoreUSA

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