Advertisement

Signaling network of Oncostatin M pathway

  • Gourav Dey
  • Aneesha Radhakrishnan
  • Nazia Syed
  • Joji Kurian Thomas
  • Arpitha Nadig
  • Kotteazeth Srikumar
  • Premendu Prakash Mathur
  • Akhilesh Pandey
  • Sze-Kwan Lin
  • Rajesh Raju
  • T. S. Keshava Prasad
Nuts and Bolts

Introduction

Oncostatin M (OSM), belonging to the IL-6 family of cytokines (Heinrich et al. 2003), was first reported and purified from U937 monocytic cells (Zarling et al. 1986; Ensoli et al. 1999; Hasegawa et al. 1999). In normal physiological condition, OSM is associated with multiple biological processes and cellular responses including growth, differentiation, and inflammation However, anti-proliferative activity of OSM against breast cancer cell line generated the interest of biomedical community on this molecule (Douglas et al. 1997, 1998). OSM was also found associated with pathological conditions such as proliferation of ovarian cancer cells (Taga and Kishimoto 1997), prostate cancer 22Rv1 cells (Hoffman et al. 1996), up-regulation of the ER chaperone Grp78/BiP in the liver cells, atherosclerotic lesions, ischemic heart disease and rheumatoid arthritis (Linsley et al. 1990; Dunham et al. 1999). The dual role of OSM in either inducing or inhibiting the proliferation of various...

Keywords

LDLR Gene Leukemia Inhibit Factor Receptor PCSK9 Gene U937 Monocytic Cell Human Proximal Tubule Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

AKT

v-akt murine thymoma viral oncogene homolog 1

JAK

Janus kinase

LIFR

Leukemia inhibiting factor

MAPK

Mitogen-activated protein kinase

OSM

Oncostatin M

OSMR-beta

OSM receptor-beta subunit

PI3K

Phosphoinositide 3-kinase

PTMs

Post-translational modifications

STAT

Signal transduction and activator of transcription

Notes

Acknowledgments

We thank the Department of Biotechnology, Government of India for research support to the Institute of Bioinformatics, Bangalore. Gourav Dey and Nazia Syed are recipients of Junior Research Fellowship from the University Grants Commission (UGC), Government of India. Aneesha Radhakrishnan is a recipient of a Senior Research Fellowship from the Council of Scientific and Industrial Research (CSIR), Government of India. We thank G. S Sameer Kumar and Renu Goel for assistance in curation.

Conflict of interest

The author(s) declared no conflicts of interests.

References

  1. Albasanz-Puig A, Murray J, Namekata M, Wijelath ES (2012) Opposing roles of STAT-1 and STAT-3 in regulating vascular endothelial growth factor expression in vascular smooth muscle cells. Biochem Biophys Res Commun 428(1):179–184PubMedCrossRefGoogle Scholar
  2. Arita K, South AP, Hans-Filho G, Sakuma TH, Lai-Cheong J, Clements S, Odashiro M, Odashiro DN, Hans-Neto G, Hans NR et al (2008) Oncostatin M receptor-beta mutations underlie familial primary localized cutaneous amyloidosis. Am J Hum Genet 82:73–80PubMedCrossRefGoogle Scholar
  3. Blanchard F, Wang Y, Kinzie E, Duplomb L, Godard A, Baumann H (2001) Oncostatin M regulates the synthesis and turnover of gp130, leukemia inhibitory factor receptor alpha, and oncostatin M receptor beta by distinct mechanisms. J Biol Chem 276:47038–47045PubMedCrossRefGoogle Scholar
  4. Boeckmann B, Bairoch A, Apweiler R, Blatter MC, Estreicher A, Gasteiger E, Martin MJ, Michoud K, O’Donovan C, Phan I, Pilbout S, Schneider M (2003) The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003. Nucleic Acids Res 31:365–370PubMedCrossRefGoogle Scholar
  5. Cao A, Wu M, Li H, Liu J (2011) Janus kinase activation by cytokine oncostatin M decreases PCSK9 expression in liver cells. J Lipid Res 52:518–530PubMedCrossRefGoogle Scholar
  6. Douglas AM, Goss GA, Sutherland RL, Hilton DJ, Berndt MC, Nicola NA, Begley CG (1997) Expression and function of members of the cytokine receptor superfamily on breast cancer cells. Oncogene 14:661–669PubMedCrossRefGoogle Scholar
  7. Douglas AM, Grant SL, Goss GA, Clouston DR, Sutherland RL, Begley CG (1998) Oncostatin M induces the differentiation of breast cancer cells. Int J Cancer 75:64–73PubMedCrossRefGoogle Scholar
  8. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R et al (1999) The DNA sequence of human chromosome 22. Nature 402:489–495PubMedCrossRefGoogle Scholar
  9. Ensoli F, Fiorelli V, DeCristofaro M, Santini Muratori D, Novi A, Vannelli B, Thiele CJ, Luzi G, Aiuti F (1999) Inflammatory cytokines and HIV-1-associated neurodegeneration: oncostatin-M produced by mononuclear cells from HIV-1-infected individuals induces apoptosis of primary neurons. J Immunol 162:6268–6277PubMedGoogle Scholar
  10. Fossey SL, Bear MD, Kisseberth WC, Pennell M, London CA (2011) Oncostatin M promotes STAT3 activation, VEGF production, and invasion in osteosarcoma cell lines. BMC Cancer 11:125PubMedCrossRefGoogle Scholar
  11. Goel R, Harsha HC, Pandey A, Prasad TSK (2012) Human protein reference database and human proteinpedia as resources for phosphoproteome analysis. Mol Biosyst 8:453–463PubMedCrossRefGoogle Scholar
  12. Goel R, Raju R, Maharudraiah J, Kumar GSS, Ghosh K, Kumar A, Lashmi PT et al (2011) A signaling network of thyroid-stimulating hormone. J Proteome Bioinforma 4:238–241Google Scholar
  13. Hamosh A, Scott AF, Amberger JS, Bocchini CA, McKusick VA (2005) Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders. Nucleic Acids Res 33:D514–D517PubMedCrossRefGoogle Scholar
  14. Hasegawa M, Sato S, Ihn H, Takehara K (1999) Enhanced production of interleukin-6 (IL-6), oncostatin M and soluble IL-6 receptor by cultured peripheral blood mononuclear cells from patients with systemic sclerosis. Rheumatology (Oxford) 38:612–617CrossRefGoogle Scholar
  15. Heinrich PC, Behrmann I, Haan S, Hermanns HM, Muller-Newen G, Schaper F (2003) Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J 374:1–20PubMedCrossRefGoogle Scholar
  16. Hoffman RC, Moy FJ, Price V, Richardson J, Kaubisch D, Frieden EA, Krakover JD, Castner BJ, King J, March CJ, Powers R (1996) Resonance assignments for oncostatin M, a 24-kDa alpha-helical protein. J Biomol NMR 7:273–282PubMedCrossRefGoogle Scholar
  17. Kandasamy K, Keerthikumar S, Raju R, Prasad TSK, Ramachandra YL, Mohan S, Pandey A (2009) PathBuilder–open source software for annotating and developing pathway resources. Bioinformatics 25:2860–2862PubMedCrossRefGoogle Scholar
  18. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D et al (2010) NetPath: a public resource of curated signal transduction pathways. Genome Biol 11:R3PubMedCrossRefGoogle Scholar
  19. Kok SH, Hou KL, Hong CY, Wang JS, Liang PC, Chang CC, Hsiao M, Yang H, Lai EH, Lin SK (2011) Simvastatin inhibits cytokine-stimulated Cyr61 expression in osteoblastic cells: a therapeutic benefit for arthritis. Arthritis Rheum 63:1010–1020PubMedCrossRefGoogle Scholar
  20. Li Q, Zhu J, Sun F, Liu L, Liu X, Yue Y (2011) Oncostatin M promotes proliferation of ovarian cancer cells through signal transducer and activator of transcription 3. Int J Mol Med 28:101–108PubMedGoogle Scholar
  21. Linsley PS, Kallestad J, Ochs V, Neubauer M (1990) Cleavage of a hydrophilic C-terminal domain increases growth-inhibitory activity of oncostatin M. Mol Cell Biol 10:1882–1890PubMedGoogle Scholar
  22. Maglott D, Ostell J, Pruitt KD, Tatusova T (2005) Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res 33:D54–D58PubMedCrossRefGoogle Scholar
  23. Migita K, Komori A, Torigoshi T, Maeda Y, Izumi Y, Jiuchi Y, Miyashita T, Nakamura M, Motokawa S, Ishibashi H (2011) CP690,550 inhibits oncostatin M-induced JAK/STAT signaling pathway in rheumatoid synoviocytes. Arthritis Res Ther 13:R72PubMedCrossRefGoogle Scholar
  24. Nanjappa V, Raju R, Muthusamy B, Sharma J, Thomas K, Nidhina PAH, Harsha HC, Pandey A, Anilkumar G, Prasad TSK (2011) A comprehensive curated reaction map of leptin signaling pathway. J Proteome Bioinforma 4:184–189Google Scholar
  25. Nicolaidou V, Wong MM, Redpath AN, Ersek A, Baban DF, Williams LM, Cope AP, Horwood NJ (2012) Monocytes induce STAT3 activation in human mesenchymal stem cells to promote osteoblast formation. PLoS One 7:e39871PubMedCrossRefGoogle Scholar
  26. O’Hara KA, Kedda MA, Thompson PJ, Knight DA (2003) Oncostatin M: an interleukin-6-like cytokine relevant to airway remodelling and the pathogenesis of asthma. Clin exp allergy: j Br Soc Allergy Clin Immunol 33:1026–1032CrossRefGoogle Scholar
  27. Prasad TSK, Kandasamy K, Pandey A (2009) Human protein reference database and human proteinpedia as discovery tools for systems biology. Methods Mol Biol 577:67–79PubMedCrossRefGoogle Scholar
  28. Raju R, Balakrishnan L, Nanjappa V, Bhattacharjee M, Getnet D, Muthusamy B, Kurian Thomas J et al. (2011a) A comprehensive manually curated reaction map of RANKL/RANK-signaling pathway. Database (Oxford) 2011: bar021Google Scholar
  29. Raju R, Nanjappa V, Balakrishnan L, Radhakrishnan A, Thomas JK, Sharma J, Tian M, Palapetta SM, Subbannayya T et al. (2011b) NetSlim:high-confidence curated signaling maps. Database (Oxford) 2011:bar032Google Scholar
  30. Ruprecht K, Kuhlmann T, Seif F, Hummel V, Kruse N, Bruck W, Rieckmann P (2001) Effects of oncostatin M on human cerebral endothelial cells and expression in inflammatory brain lesions. J Neuropathol Exp Neurol 60:1087–1098PubMedGoogle Scholar
  31. Sarkozi R, Hauser C, Noppert SJ, Kronbichler A, Pirklbauer M, Haller VM, Grillari J, Grillari-Voglauer R, Mayer G, Schramek H (2011) Oncostatin M is a novel inhibitor of TGF-beta1-induced matricellular protein expression. Am J Physiol Renal Physiol 301:F1014–F1025PubMedCrossRefGoogle Scholar
  32. Schaefer LK, Wang S, Schaefer TS (2000) Oncostatin M activates stat DNA binding and transcriptional activity in primary human fetal astrocytes: low- and high-passage cells have distinct patterns of stat activation. Cytokine 12:1647–1655PubMedCrossRefGoogle Scholar
  33. Taga T, Kishimoto T (1997) Gp130 and the interleukin-6 family of cytokines. Annu Rev Immunol 15:797–819PubMedCrossRefGoogle Scholar
  34. Tanaka M, Miyajima A (2003) Oncostatin M, a multifunctional cytokine. Rev Physiol Biochem Pharmacol 149:39–52PubMedCrossRefGoogle Scholar
  35. Thoma B, Bird TA, Friend DJ, Gearing DP, Dower SK (1994) Oncostatin M and leukemia inhibitory factor trigger overlapping and different signals through partially shared receptor complexes. J Biol Chem 269:6215–6222PubMedGoogle Scholar
  36. Tu HJ, Lin TH, Chiu YC, Tang CH, Yang RS, Fu WM (2012) Enhancement of placenta growth factor expression by oncostatin M in human rheumatoid arthritis synovial fibroblasts. J Cell PhysiolGoogle Scholar
  37. Van Wagoner NJ, Choi C, Repovic P, Benveniste EN (2000) Oncostatin M regulation of interleukin-6 expression in astrocytes: biphasic regulation involving the mitogen-activated protein kinases ERK1/2 and p38. J Neurochem 75:563–575PubMedCrossRefGoogle Scholar
  38. Weiss TW, Kvakan H, Kaun C, Zorn G, Speidl WS, Pfaffenberger S, Maurer G, Huber K, Wojta J (2005) The gp130 ligand oncostatin M regulates tissue inhibitor of metalloproteinases-1 through ERK1/2 and p38 in human adult cardiac myocytes and in human adult cardiac fibroblasts: a possible role for the gp130/gp130 ligand system in the modulation of extracellular matrix degradation in the human heart. J Mol Cell Cardiol 39:545–551PubMedCrossRefGoogle Scholar
  39. Zarling JM, Shoyab M, Marquardt H, Hanson MB, Lioubin MN, Todaro GJ (1986) Oncostatin M: a growth regulator produced by differentiated histiocytic lymphoma cells. Proc Natl Acad Sci U S A 83:9739–9743PubMedCrossRefGoogle Scholar
  40. Zhang F, Li C, Halfter H, Liu J (2003) Delineating an oncostatin M-activated STAT3 signaling pathway that coordinates the expression of genes involved in cell cycle regulation and extracellular matrix deposition of MCF-7 cells. Oncogene 22:894–905PubMedCrossRefGoogle Scholar

Copyright information

© The International CCN Society 2012

Authors and Affiliations

  • Gourav Dey
    • 1
  • Aneesha Radhakrishnan
    • 1
    • 2
  • Nazia Syed
    • 1
    • 2
  • Joji Kurian Thomas
    • 1
    • 3
  • Arpitha Nadig
    • 4
  • Kotteazeth Srikumar
    • 2
  • Premendu Prakash Mathur
    • 2
    • 7
  • Akhilesh Pandey
    • 5
  • Sze-Kwan Lin
    • 6
  • Rajesh Raju
    • 1
  • T. S. Keshava Prasad
    • 1
    • 3
  1. 1.Institute of BioinformaticsInternational Tech ParkBangaloreIndia
  2. 2.Department of Biochemistry and Molecular Biology, School of Life SciencesPondicherry UniversityPuducherryIndia
  3. 3.School of BiotechnologyAmrita Vishwa VidhyapeetamKollamIndia
  4. 4.Department of BioinformaticsKuvempu UniversityShankaraghattaIndia
  5. 5.McKusick-Nathans Institute of Genetic Medicine and Departments of Biological Chemistry, Pathology and OncologyJohns Hopkins University School of MedicineBaltimoreUSA
  6. 6.School of Dentistry, College of MedicineNational Taiwan UniversityTaipeiTaiwan
  7. 7.KIIT UniversityBhubaneswarIndia

Personalised recommendations