Signaling network of Oncostatin M pathway

  • Gourav Dey
  • Aneesha Radhakrishnan
  • Nazia Syed
  • Joji Kurian Thomas
  • Arpitha Nadig
  • Kotteazeth Srikumar
  • Premendu Prakash Mathur
  • Akhilesh Pandey
  • Sze-Kwan Lin
  • Rajesh Raju
  • T. S. Keshava Prasad
Nuts and Bolts


Oncostatin M (OSM), belonging to the IL-6 family of cytokines (Heinrich et al. 2003), was first reported and purified from U937 monocytic cells (Zarling et al. 1986; Ensoli et al. 1999; Hasegawa et al. 1999). In normal physiological condition, OSM is associated with multiple biological processes and cellular responses including growth, differentiation, and inflammation However, anti-proliferative activity of OSM against breast cancer cell line generated the interest of biomedical community on this molecule (Douglas et al. 1997, 1998). OSM was also found associated with pathological conditions such as proliferation of ovarian cancer cells (Taga and Kishimoto 1997), prostate cancer 22Rv1 cells (Hoffman et al. 1996), up-regulation of the ER chaperone Grp78/BiP in the liver cells, atherosclerotic lesions, ischemic heart disease and rheumatoid arthritis (Linsley et al. 1990; Dunham et al. 1999). The dual role of OSM in either inducing or inhibiting the proliferation of various...


LDLR Gene Leukemia Inhibit Factor Receptor PCSK9 Gene U937 Monocytic Cell Human Proximal Tubule Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



v-akt murine thymoma viral oncogene homolog 1


Janus kinase


Leukemia inhibiting factor


Mitogen-activated protein kinase


Oncostatin M


OSM receptor-beta subunit


Phosphoinositide 3-kinase


Post-translational modifications


Signal transduction and activator of transcription



We thank the Department of Biotechnology, Government of India for research support to the Institute of Bioinformatics, Bangalore. Gourav Dey and Nazia Syed are recipients of Junior Research Fellowship from the University Grants Commission (UGC), Government of India. Aneesha Radhakrishnan is a recipient of a Senior Research Fellowship from the Council of Scientific and Industrial Research (CSIR), Government of India. We thank G. S Sameer Kumar and Renu Goel for assistance in curation.

Conflict of interest

The author(s) declared no conflicts of interests.


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Copyright information

© The International CCN Society 2012

Authors and Affiliations

  • Gourav Dey
    • 1
  • Aneesha Radhakrishnan
    • 1
    • 2
  • Nazia Syed
    • 1
    • 2
  • Joji Kurian Thomas
    • 1
    • 3
  • Arpitha Nadig
    • 4
  • Kotteazeth Srikumar
    • 2
  • Premendu Prakash Mathur
    • 2
    • 7
  • Akhilesh Pandey
    • 5
  • Sze-Kwan Lin
    • 6
  • Rajesh Raju
    • 1
  • T. S. Keshava Prasad
    • 1
    • 3
  1. 1.Institute of BioinformaticsInternational Tech ParkBangaloreIndia
  2. 2.Department of Biochemistry and Molecular Biology, School of Life SciencesPondicherry UniversityPuducherryIndia
  3. 3.School of BiotechnologyAmrita Vishwa VidhyapeetamKollamIndia
  4. 4.Department of BioinformaticsKuvempu UniversityShankaraghattaIndia
  5. 5.McKusick-Nathans Institute of Genetic Medicine and Departments of Biological Chemistry, Pathology and OncologyJohns Hopkins University School of MedicineBaltimoreUSA
  6. 6.School of Dentistry, College of MedicineNational Taiwan UniversityTaipeiTaiwan
  7. 7.KIIT UniversityBhubaneswarIndia

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