Signaling network of Oncostatin M pathway
Oncostatin M (OSM), belonging to the IL-6 family of cytokines (Heinrich et al. 2003), was first reported and purified from U937 monocytic cells (Zarling et al. 1986; Ensoli et al. 1999; Hasegawa et al. 1999). In normal physiological condition, OSM is associated with multiple biological processes and cellular responses including growth, differentiation, and inflammation However, anti-proliferative activity of OSM against breast cancer cell line generated the interest of biomedical community on this molecule (Douglas et al. 1997, 1998). OSM was also found associated with pathological conditions such as proliferation of ovarian cancer cells (Taga and Kishimoto 1997), prostate cancer 22Rv1 cells (Hoffman et al. 1996), up-regulation of the ER chaperone Grp78/BiP in the liver cells, atherosclerotic lesions, ischemic heart disease and rheumatoid arthritis (Linsley et al. 1990; Dunham et al. 1999). The dual role of OSM in either inducing or inhibiting the proliferation of various...
KeywordsLDLR Gene Leukemia Inhibit Factor Receptor PCSK9 Gene U937 Monocytic Cell Human Proximal Tubule Cell
v-akt murine thymoma viral oncogene homolog 1
Leukemia inhibiting factor
Mitogen-activated protein kinase
OSM receptor-beta subunit
Signal transduction and activator of transcription
We thank the Department of Biotechnology, Government of India for research support to the Institute of Bioinformatics, Bangalore. Gourav Dey and Nazia Syed are recipients of Junior Research Fellowship from the University Grants Commission (UGC), Government of India. Aneesha Radhakrishnan is a recipient of a Senior Research Fellowship from the Council of Scientific and Industrial Research (CSIR), Government of India. We thank G. S Sameer Kumar and Renu Goel for assistance in curation.
Conflict of interest
The author(s) declared no conflicts of interests.
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