A multicellular signal transduction network of AGE/RAGE signaling
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Advanced glycation end products (AGEs) are heterogeneous glycated products of proteins, lipids and nucleotides. The major receptor for AGEs, known as receptor for advanced glycation end products (RAGE or AGER), is a multi-ligand transmembrane receptor of immunoglobulin superfamily. It has an extracellular region, a transmembrane domain and a short cytoplasmic domain. Extracellular region of RAGE consists of one V type (critical for ligand binding) and two C type immunoglobulin domains (Schmidt et al. 1994a, b). Although the short cytoplasmic tail of 43 amino acid residues is found to be important for the signaling events mediated by RAGE, it does not have any known domain or motif (Neeper et al. 1992). The other cell surface receptors for AGEs include dolichyl-diphosphooligosaccharide-protein glycosyltransferase (AGE-R1) (Li et al. 1996), protein kinase C substrate, 80KH phosphoprotein (AGE-R2) (Goh et al. 1996), galectin-3 (AGE-R3) (Vlassara et al. 1995), and class A...
KeywordsPentosidine Diverse Cell Type System Biology Markup Cell Type Specific Effect Standard Data Exchange
Receptor for advanced glycation end products
High mobility group box protein 1
Biological PAthway eXchange
Systems Biology Markup Language
Proteomics Standards Initiative for Molecular Interaction
We thank the Department of Biotechnology (DBT), Government of India for research support to the Institute of Bioinformatics, Bangalore. Varot K. Sandhya is a recipient of INSPIRE Fellowship from the Department of Science and Technology, Government of India. H. C. Harsha is a Wellcome Trust-DBT India Alliance Early Career Fellow.
Conflict of interests
The author(s) declared no conflicts of interests.
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