A multicellular signal transduction network of AGE/RAGE signaling

  • Sowmya Soman
  • Rajesh Raju
  • Varot K. Sandhya
  • Jayshree Advani
  • Aafaque Ahmad Khan
  • H. C. Harsha
  • T. S. Keshava Prasad
  • P. R. Sudhakaran
  • Akhilesh Pandey
  • Puneeth K. Adishesha
Nuts and Bolts


Advanced glycation end products (AGEs) are heterogeneous glycated products of proteins, lipids and nucleotides. The major receptor for AGEs, known as receptor for advanced glycation end products (RAGE or AGER), is a multi-ligand transmembrane receptor of immunoglobulin superfamily. It has an extracellular region, a transmembrane domain and a short cytoplasmic domain. Extracellular region of RAGE consists of one V type (critical for ligand binding) and two C type immunoglobulin domains (Schmidt et al. 1994a, b). Although the short cytoplasmic tail of 43 amino acid residues is found to be important for the signaling events mediated by RAGE, it does not have any known domain or motif (Neeper et al. 1992). The other cell surface receptors for AGEs include dolichyl-diphosphooligosaccharide-protein glycosyltransferase (AGE-R1) (Li et al. 1996), protein kinase C substrate, 80KH phosphoprotein (AGE-R2) (Goh et al. 1996), galectin-3 (AGE-R3) (Vlassara et al. 1995), and class A...


Pentosidine Diverse Cell Type System Biology Markup Cell Type Specific Effect Standard Data Exchange 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Receptor for advanced glycation end products


High mobility group box protein 1


Soluble RAGE






Matrix metalloproteinases


Post-translational modifications


Protein-protein interactions


Biological PAthway eXchange


Systems Biology Markup Language


Proteomics Standards Initiative for Molecular Interaction



We thank the Department of Biotechnology (DBT), Government of India for research support to the Institute of Bioinformatics, Bangalore. Varot K. Sandhya is a recipient of INSPIRE Fellowship from the Department of Science and Technology, Government of India. H. C. Harsha is a Wellcome Trust-DBT India Alliance Early Career Fellow.

Conflict of interests

The author(s) declared no conflicts of interests.


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Copyright information

© The International CCN Society 2012

Authors and Affiliations

  • Sowmya Soman
    • 1
  • Rajesh Raju
    • 1
  • Varot K. Sandhya
    • 1
  • Jayshree Advani
    • 1
  • Aafaque Ahmad Khan
    • 1
  • H. C. Harsha
    • 1
  • T. S. Keshava Prasad
    • 1
  • P. R. Sudhakaran
    • 2
  • Akhilesh Pandey
    • 3
    • 4
    • 5
    • 6
  • Puneeth K. Adishesha
    • 1
  1. 1.Institute of BioinformaticsInternational Technology ParkBangaloreIndia
  2. 2.Department of Computational Biology and Bioinformatics, State Inter-University Centre of Excellence in BioinformaticsUniversity of KeralaThiruvananthapuramIndia
  3. 3.McKusick-Nathans Institute of Genetic MedicineJohns Hopkins University School of MedicineBaltimoreUSA
  4. 4.Department of Biological ChemistryJohns Hopkins University School of MedicineBaltimoreUSA
  5. 5.Department of OncologyJohns Hopkins University School of MedicineBaltimoreUSA
  6. 6.Department of PathologyJohns Hopkins University School of MedicineBaltimoreUSA

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