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Mastering a mediator: blockade of CCN-2 shows early promise in human diabetic kidney disease

  • Commentary
  • Published:
Journal of Cell Communication and Signaling Aims and scope

Abstract

In diabetes complications, CCN-2 (known originally as CTGF) has been implicated in diabetic nephropathy both as a marker and a mediator of disease. This commentary addresses CCN-2 in diabetic nephropathy, in the context of the recent publication of the first human study to inhibit CCN-2 bioactivity in diabetic kidney disease.

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Abbreviations

DN:

Diabetic nephropathy

GFR:

Glomerular filtration rate

CKD:

Chronic kidney disease

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  1. Sydney Medical School, Discipline of Medicine and the Bosch Institute, The University of Sydney, Sydney, New South Wales, 200, Australia

    Stephen M. Twigg

  2. Department of Endocrinology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia

    Stephen M. Twigg

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Twigg, S.M. Mastering a mediator: blockade of CCN-2 shows early promise in human diabetic kidney disease. J. Cell Commun. Signal. 4, 189–196 (2010). https://doi.org/10.1007/s12079-010-0102-2

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