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It’s a knockout: CCN3 suppresses neointimal thickening

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Journal of Cell Communication and Signaling Aims and scope

Abstract

The role of CCN proteins in vivo is only just becoming understood. A prototypical member of the CCN family, CCN3 suppresses proliferation. In a study in press, Shimoyama and colleagues show that mice lacking CCN3 have a hyperproliferative response to vascular injury. These data, along with other recent observations, suggest that CCN3 may represent a novel therapy for hyperproliferative diseases.

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Authors and Affiliations

  1. CIHR Group in Skeletal Development and Remodeling, Division of Oral Biology, Department of Dentistry, Schulich School of Medicine and Dentistry, Dental Sciences Building, University of Western Ontario, London, ON, Canada, N6A 5C1

    Andrew Leask

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  1. Andrew Leask
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Correspondence to Andrew Leask.

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Leask, A. It’s a knockout: CCN3 suppresses neointimal thickening. J. Cell Commun. Signal. 4, 109–110 (2010). https://doi.org/10.1007/s12079-010-0086-y

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  • DOI: https://doi.org/10.1007/s12079-010-0086-y

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