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CCN2 YAPs at cancer

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Journal of Cell Communication and Signaling Aims and scope


The YAP transcription coactivator has been implicated as an oncogene and is amplified in human cancers. Previously, it has been shown that CCN2 (connective tissue growth factor, CTGF) is a target of the tumor promoting YAP and its transcription factor target TEAD. A recent report in Genes and Development by Zhao and colleagues (Genes Dev 22:1962–1971 2008) has extended these initial observations to show that CCN2 plays an important role in the growth-promoting function of YAP. These data confirm the role of CCN2 as a key oncogenic mediator. This report briefly summarizes these findings.

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Correspondence to Andrew Leask.

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Leask, A. CCN2 YAPs at cancer. J. Cell Commun. Signal. 2, 47–48 (2008).

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