Reversal of NASH fibrosis with pharmacotherapy


NAFLD is a spectrum of liver disease starting with fatty liver at one end of the spectrum and cirrhosis or liver cancer at the other end. Worldwide, NAFLD has become one of the most common liver diseases and it has also become one of the leading indications for liver transplantation. Our understanding of the NAFLD epidemiology, pathogenesis and its progression to cirrhosis has improved over the last 2 decades. Currently, however, there are no FDA-approved treatment options for fibrosis resulting from NAFLD. A number of compounds targeting multiple pathways involved in the progression of NAFLD are currently in phase 2–3 trials. In this review, we will briefly discuss the epidemiology, the pathogenesis and the current status of treatment of NAFLD.

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JJA and PJT contributed to the drafting of the article or critical revision of important intellectual content.

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Correspondence to Paul J. Thuluvath.

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Joseph J. Alukal and Paul J. Thuluvath declare that they have no competing interests.

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Alukal, J.J., Thuluvath, P.J. Reversal of NASH fibrosis with pharmacotherapy. Hepatol Int 13, 534–545 (2019).

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  • NASH
  • Antifibrotic agents