Hepatology International

, Volume 12, Issue 2, pp 158–166 | Cite as

Spectrum of histopathological changes in patients with non-cirrhotic portal fibrosis

  • Abhijit Chougule
  • Archana Rastogi
  • Rakhi Maiwall
  • Chhagan Bihari
  • Vikrant Sood
  • Shiv Kumar Sarin
Original Article


Background and aims

Non-cirrhotic portal fibrosis (NCPF) is a clinical disorder characterized by features of portal hypertension in the absence of significant fibrosis. It is one of the commonest causes of portal hypertension in India. This study aimed to analyze histomorphological spectrum of NCPF in detail.

Methods and Results

There were 67 specimens from 66 patients which included 43 (65.2%) male and 23 (34.8%) female patients with a mean age of 31 years (range: 7–61 years). The liver function tests showed only a mild derangement. The average length of biopsy was 1.4 cm (median: 1.2 cm, range: 0.8–3.4 cm) and the mean number of portal tracts per biopsy was 11.1 (median: 10, range: 5–30). Most cases showed a combination of histological features; the mean number of histological features per biopsy was 7.4 (median: 7, range: 3–12). Obliterative portal venopathy was seen in 47.8% cases. Portal angiomatosis (61.2%), paraportal shunt vessels (61.2%), portal vein dilatation (74.6%), hypoplastic portal tracts (56.7%), megasinusoids (64.1%), and abnormally dilated central veins (64.1%) were other prevalent features. Portal/periportal fibrosis and perisinusoidal fibrosis were seen in 77.6% and 61.2% cases; none showed bridging fibrosis or cirrhosis. The median hepatic venous pressure gradient (HVPG) and liver stiffness (LS) values were 8 mm of Hg (range: 5–20 mm of Hg) and 9.2 kPa (range: 4.4–26.3 kPa). There was no correlation of HVPG or LS with either portal/periportal fibrosis or perisinusoidal fibrosis.


Due to relatively non-specific and non-pathognomonic nature, a combination of different histological features in the absence of significant fibrosis and appropriate clinico-radiological background is needed for diagnosing NCPF.


Non-cirrhotic portal fibrosis Histopathology Hepatic venous pressure gradient Liver stiffness 


Compliance with ethical standards

Conflict of interest

Abhijit Chougule, Archana Rastogi, Rakhi Maiwall, Chhagan Bihari, Vikrant Sood, and Shiv Kumar Sarin, declare that they have no conflict of interest.

Ethical approval

The study was approved by the Institutional Ethics Committee (IEC)/ Institutional Review Board (IRB) (IEC/2017/49/MA09). All authors are in compliance with ethical standards for this study.


There is no funding or grant to disclose for this work by any of the authors.


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Copyright information

© Asian Pacific Association for the Study of the Liver 2018

Authors and Affiliations

  • Abhijit Chougule
    • 1
  • Archana Rastogi
    • 1
  • Rakhi Maiwall
    • 2
  • Chhagan Bihari
    • 1
  • Vikrant Sood
    • 3
  • Shiv Kumar Sarin
    • 2
  1. 1.Department of PathologyInstitute of Liver and Biliary SciencesNew DelhiIndia
  2. 2.Department of HepatologyInstitute of Liver and Biliary SciencesNew DelhiIndia
  3. 3.Department of Pediatric HepatologyInstitute of Liver and Biliary SciencesNew DelhiIndia

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