Hepatology International

, Volume 12, Issue 2, pp 174–180 | Cite as

Psychiatric comorbidities among patients undergoing liver transplantation in South Korea: a nationwide population-based study

  • Jaesung Heo
  • O Kyu Noh
  • Young-Taek Oh
  • Mison Chun
  • Logyoung Kim
Original Article



The aim of this study was to analyze the prevalence of mental disorders in patients undergoing liver transplantation (LT) based on claims data from the Health Insurance Review and Assessment Service (HIRA) in South Korea.


We confirmed mental disorders in a nationwide cohort of 3758 patients receiving LT between January 2010 and December 2014. We categorized the prevalence of mental disorders based on patient age at the time of LT.


A total of 288 patients for LT were diagnosed with a mental disorder 1 year before their cancer diagnosis. Of those patients, depression was present in 90 (31.25%) and anxiety in 92 (31.9%) patients at the first diagnosis. The overall frequency of mental disorders peaked just before LT, and substance abuse was the most prevalent mental disorder before LT. The risk of mental disorders after LT was significantly lower in those with hepatocellular carcinoma (HCC) than in those without HCC (hazard ratio = 1.70, p < 0.001).


Mental disorders in patients receiving LT showed different patterns of prevalence depending on age at the time of surgery and the nature of underlying diseases. Personalized intervention based on patient characteristics could improve the quality of life.


Depression Anxiety Liver transplantation Quality of life 


Compliance with ethical standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Supplementary material

12072_2018_9849_MOESM1_ESM.tif (670 kb)
Supplement 1. A) Mental disorders in hepatocellular cell carcinoma versus non-hepatocellular cell carcinoma patients. B) Mental disorders in subgroup of patients with non-hepatocellular cell carcinoma. (TIFF 670 kb)


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Copyright information

© Asian Pacific Association for the Study of the Liver 2018

Authors and Affiliations

  • Jaesung Heo
    • 1
  • O Kyu Noh
    • 1
    • 2
    • 3
  • Young-Taek Oh
    • 1
  • Mison Chun
    • 1
  • Logyoung Kim
    • 4
  1. 1.Department of Radiation OncologyAjou University School of MedicineSuwonSouth Korea
  2. 2.Department of Biomedical InformaticsAjou University School of MedicineSuwonSouth Korea
  3. 3.Office of BiostatisticsAjou University School of MedicineSuwonSouth Korea
  4. 4.Health Insurance Review and Assessment ServiceSeoulSouth Korea

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