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Hepatology International

, Volume 8, Supplement 2, pp 514–525 | Cite as

Growth factors enhance liver regeneration in acute-on-chronic liver failure

  • Chandan Kumar Kedarisetty
  • Lovkesh Anand
  • Arshi Khanam
  • Anupam Kumar
  • Archana Rastogi
  • Rakhi Maiwall
  • Shiv Kumar SarinEmail author
Supplement Issue: ALPD

Abstract

Acute-on-chronic liver failure is a distinct syndrome characterized by a rapid progression of liver disease culminating in organ failure and death. The only definitive treatment is liver transplantation. However, there is a possible element of reversibility and hepatic regeneration if the acute insult can be tided over. Exogenously administered growth factors may stimulate hepatocytes, hepatic progenitor cells and bone marrow-derived cells to supplement hepatic regeneration. The proposed review is intended to provide an in-depth analysis of the individual components of hepatic and bone marrow niches and highlight the growing role of various growth factors in liver regeneration in health and in liver failure.

Keywords

Liver failure Liver regeneration Growth factors 

Notes

Compliance with ethical requirements and Conflict of interest

None.

Disclosures

None.

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Copyright information

© Asian Pacific Association for the Study of the Liver 2014

Authors and Affiliations

  • Chandan Kumar Kedarisetty
    • 1
  • Lovkesh Anand
    • 1
  • Arshi Khanam
    • 2
  • Anupam Kumar
    • 2
  • Archana Rastogi
    • 3
  • Rakhi Maiwall
    • 1
  • Shiv Kumar Sarin
    • 1
    Email author
  1. 1.Department of HepatologyInstitute of Liver and Biliary SciencesNew DelhiIndia
  2. 2.Department of ResearchInstitute of Liver and Biliary SciencesNew DelhiIndia
  3. 3.Department of PathologyInstitute of Liver and Biliary SciencesNew DelhiIndia

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