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Immunity and inflammatory signaling in alcoholic liver disease

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Abstract

The pathogenesis of alcoholic liver disease (ALD) is multifactorial and characterized by steatosis, steatohepatitis and cirrhosis. Several signaling pathways in different liver cell types that contribute to the development and progression of alcoholic liver injury have been identified. Among these, immune cells and signaling pathways are the most prominent and central to ALD. Both innate and adaptive immune responses contribute to ALD. The key features of inflammatory pathways in ALD including liver innate and adaptive immune cell types, signaling receptors/pathways, and pro- and antiinflammatory/protective responses are summarized here.

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Acknowledgements

This work was supported by PHS Grant No. AA017986 from the National Institute of Alcohol Abuse and Alcoholism (NIAAA), and PR100284 and PR120783 from the Department of Defense (DoD). Its contents are the sole responsibility of the authors and do not necessarily represent the views of the NIAAA or DoD.

Compliance with ethical requirements and Conflict of interest

This article does not contain any studies with human or animal subjects performed by any of the authors. Pranoti Mandrekar and Aditya Ambade declare that they do not have any conflicts of interest.

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Authors and Affiliations

  1. Department of Medicine, University of Massachusetts Medical School, LRB 221, 364 Plantation Street, Worcester, MA, 01605, USA

    Pranoti Mandrekar

  2. Department of Medicine, University of Massachusetts Medical School, LRB 270i, 364 Plantation Street, Worcester, MA, 01605, USA

    Aditya Ambade

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  1. Pranoti Mandrekar
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  2. Aditya Ambade
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Correspondence to Pranoti Mandrekar.

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Mandrekar, P., Ambade, A. Immunity and inflammatory signaling in alcoholic liver disease. Hepatol Int 8 (Suppl 2), 439–446 (2014). https://doi.org/10.1007/s12072-014-9518-8

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  • DOI: https://doi.org/10.1007/s12072-014-9518-8

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