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A nationwide population-based study shows increasing incidence of cholangiocarcinoma

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Abstract

Purpose

An increasing incidence of cholangiocarcinoma (CCA) has been reported in Western countries, but evidence is lacking in Asia. We investigated the incidence of CCA in a nationwide cohort.

Patients and methods

We conducted a nationwide cohort study based on data from the Taiwan National Health Insurance Research Database (NHIRD) between 1998 and 2008. A total of 6,491 CCA patients were recruited. Adjusted incidences, cumulative incidences, and stratified analyses were used to detect trends regarding CCA incidence in Taiwan.

Results

The incidence of CCA increased by 2.01-fold, from 1.79 in 1998 to 3.60 in 2008 per 100,000 persons. For extrahepatic CCA, the incidence increased by 1.5-fold from 0.48 to 0.73 per 100,000. Intrahepatic CCA increased by 3.0-fold from 0.72 to 2.19 per 100,000. The rising incidence of CCA was observed across all sexes and ages, especially in those older than 65 years of age. The proportion of CCA patients who underwent surgery and the overall survival rates remained stable.

Conclusions

The incidence of both intrahepatic and extrahepatic CCA increased significantly between 1998 and 2008. Rising trends were observed among different ages and sexes, especially in the elderly population.

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Acknowledgements

Financial support by Taiwan National Health Research Institutes (Grant number: PH-100-PP54) and Taichung Veterans General Hospital (Grant number: TCVGH-1003303C).

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Authors and Affiliations

  1. Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan

    Teng-Yu Lee

  2. Division of Gastroenterology and Hepatology, Taichung Veterans General Hospital, Taichung, Taiwan

    Teng-Yu Lee, Hsiu J. Ho, Tzu-Ting Chen & Chun-Ying Wu

  3. Department of Medicine, Chung Shan Medical University, Taichung, Taiwan

    Teng-Yu Lee

  4. Division of Gastroenterology, National Taiwan University Hospital, Taipei, Taiwan

    Jaw-Town Lin & Ming-Shiang Wu

  5. Department of Internal Medicine, E-Da Hospital and I-Shou University, Kaohsiung, Taiwan

    Jaw-Town Lin

  6. Center for Health Policy Research and Development, National Health Research Institutes, Miaoli, Taiwan

    Jaw-Town Lin & Ken N. Kuo

  7. Faculty of Medicine, School of Medicine, National Yang-Ming University, 155, Sec. 2, Linong Street, Taipei, 112, Taiwan

    Chun-Ying Wu

  8. Department of Public Health, China Medical University, Taichung, Taiwan

    Chun-Ying Wu

  9. Department of Life Sciences, National Chung-Hsing University, Taichung, Taiwan

    Chun-Ying Wu

Authors
  1. Teng-Yu Lee
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  2. Jaw-Town Lin
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  3. Ken N. Kuo
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  4. Ming-Shiang Wu
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  5. Hsiu J. Ho
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  7. Chun-Ying Wu
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Corresponding author

Correspondence to Chun-Ying Wu.

Electronic supplementary material

Below is the link to the electronic supplementary material.

12072_2012_9369_MOESM1_ESM.pdf

Supplementary Fig. 1 The proportion of patients with overall biliary cholangiocarcinoma who received operation (OP) on the liver between 1998 and 2008. (PDF 9 kb)

12072_2012_9369_MOESM2_ESM.pdf

Supplementary Fig. 2 The 1-year, 2-year and 3-year cumulative mortality rates of patients with overall biliary cholangiocarcinoma between 1998 and 2008. (PDF 10 kb)

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Lee, TY., Lin, JT., Kuo, K.N. et al. A nationwide population-based study shows increasing incidence of cholangiocarcinoma. Hepatol Int 7, 226–232 (2013). https://doi.org/10.1007/s12072-012-9369-0

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  • DOI: https://doi.org/10.1007/s12072-012-9369-0

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